6E4W

Structure of AMPK bound to activator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	5'-AMP-activated protein kinase catalytic subunit alpha-1	polymer	503	57779.1	1	UniProt (P54645) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB	Rattus norvegicus (Rat)	AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1
2	B	5'-AMP-activated protein kinase subunit beta-1	polymer	204	23097.2	1	UniProt (P80386) Pfam (PF16561) Pfam (PF04739) In PDB	Rattus norvegicus (Rat)	AMPKb,5'-AMP-activated protein kinase 40 kDa subunit
3	C	5'-AMP-activated protein kinase subunit gamma-1	polymer	330	37434.1	1	UniProt (P80385) Pfam (PF00571) In PDB	Rattus norvegicus (Rat)	AMPKg
4	A	STAUROSPORINE	non-polymer		466.5	1	Chemie (STU)
5	A	1-O-(4,6-difluoro-5-{4-[(2S)-oxan-2-yl]phenyl}-1H-indole-3-carbonyl)-beta-D-glucopyranuronic acid	non-polymer		533.5	1	Chemie (HUG)
6	A	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	C	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP)
8	C	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
9	C	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)

Sequence modifications

A: 0 - 516 (UniProt: P54645)

PDB	External Database	Details
Gly -1	-	expression tag

A: 525 - 548 (UniProt: P54645)

PDB	External Database	Details
Ala 517	-	linker
Ser 518	-	linker
Gly 519	-	linker
Gly 520	-	linker
Pro 521	-	linker
Gly 522	-	linker
Gly 523	-	linker
Ser 524	-	linker

B: 68 - 270 (UniProt: P80386)

PDB	External Database	Details
Met 67	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	118310.5
Non-Polymers*	Number of molecules	9
	Total formula weight	2324.1
All*	Total formula weight	120634.5

*Water molecules are not included.