6AEJ
Crystal structure of human FTO in complex with small-molecule inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO | polymer | 470 | 54122.0 | 1 | UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB | Homo sapiens (Human) | |
2 | A | (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile | non-polymer | 319.3 | 1 | Chemie (7YC) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 32 - 159 (UniProt: Q9C0B1)
A: 186 - 505 (UniProt: Q9C0B1)
PDB | External Database | Details |
---|---|---|
Met 11 | - | expression tag |
Gly 12 | - | expression tag |
Ser 13 | - | expression tag |
Ser 14 | - | expression tag |
His 15 | - | expression tag |
His 16 | - | expression tag |
His 17 | - | expression tag |
His 18 | - | expression tag |
His 19 | - | expression tag |
His 20 | - | expression tag |
Ser 21 | - | expression tag |
Ser 22 | - | expression tag |
Gly 23 | - | expression tag |
Leu 24 | - | expression tag |
Val 25 | - | expression tag |
Pro 26 | - | expression tag |
Arg 27 | - | expression tag |
Gly 28 | - | expression tag |
Ser 29 | - | expression tag |
His 30 | - | expression tag |
Met 31 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 185 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54122.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 384.7 | |
All* | Total formula weight | 54506.7 |