6AEJ

Crystal structure of human FTO in complex with small-molecule inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO	polymer	470	54122.0	1	UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB	Homo sapiens (Human)
2	A	(E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile	non-polymer		319.3	1	Chemie (7YC)
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A: 32 - 159 (UniProt: Q9C0B1)

PDB	External Database	Details
Met 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ser 22	-	expression tag
Gly 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Pro 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
Met 31	-	expression tag

A: 186 - 505 (UniProt: Q9C0B1)

PDB	External Database	Details
Ser 185	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54122.0
Non-Polymers*	Number of molecules	2
	Total formula weight	384.7
All*	Total formula weight	54506.7

*Water molecules are not included.