6AD9
Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Peroxisome proliferator-activated receptor gamma | polymer | 287 | 32693.8 | 1 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | B | 12-mer peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 12 | 1265.6 | 1 | UniProt (Q9UBK2) In PDB | Homo sapiens | PGC1-alpha |
| 3 | A | 3-[(1E)-1-{8-[(4-methyl-2-propyl-1H-benzimidazol-1-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}ethyl]-1,2,4-oxadiazol-5(4H)-one | non-polymer | 492.6 | 1 | Chemie (KK4) | |||
| 4 | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 195 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 191 | - | expression tag |
| Ser 192 | - | expression tag |
| His 193 | - | expression tag |
| Met 194 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33959.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 492.6 | |
| All* | Total formula weight | 34452.0 |
