5ZRF
Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | DNA topoisomerase 2-beta | polymer | 803 | 91928.4 | 2 | UniProt (Q02880) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) In PDB | Homo sapiens (Human) | DNA topoisomerase II,beta isozyme |
| 2 | C, E | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3') | polymer | 8 | 2436.6 | 2 | synthetic construct | ||
| 3 | D, F | DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3') | polymer | 12 | 4038.0 | 2 | synthetic construct | ||
| 4 | A, B, D, F | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 5 | D, F | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | non-polymer | 588.6 | 2 | Chemie (EVP) | |||
| 6 | water | water | 18.0 | 524 | Chemie (HOH) |
Sequence modifications
A, B: 445 - 1201 (UniProt: Q02880)
| PDB | External Database | Details |
|---|---|---|
| Met 419 | - | expression tag |
| Ala 420 | - | expression tag |
| Ser 421 | - | expression tag |
| Trp 422 | - | expression tag |
| Ser 423 | - | expression tag |
| His 424 | - | expression tag |
| Pro 425 | - | expression tag |
| Gln 426 | - | expression tag |
| Phe 427 | - | expression tag |
| Glu 428 | - | expression tag |
| Lys 429 | - | expression tag |
| Gly 430 | - | expression tag |
| Ala 431 | - | expression tag |
| Asp 432 | - | expression tag |
| Asp 433 | - | expression tag |
| Asp 434 | - | expression tag |
| Asp 435 | - | expression tag |
| Lys 436 | - | expression tag |
| Val 437 | - | expression tag |
| Pro 438 | - | expression tag |
| Asp 439 | - | expression tag |
| Pro 440 | - | expression tag |
| Thr 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Val 443 | - | expression tag |
| Asp 444 | - | expression tag |
| Gly 1202 | - | expression tag |
| Ala 1203 | - | expression tag |
| Pro 1204 | - | expression tag |
| Gly 1205 | - | expression tag |
| Phe 1206 | - | expression tag |
| Ser 1207 | - | expression tag |
| Ser 1208 | - | expression tag |
| Ile 1209 | - | expression tag |
| Ser 1210 | - | expression tag |
| Ala 1211 | - | expression tag |
| His 1212 | - | expression tag |
| His 1213 | - | expression tag |
| His 1214 | - | expression tag |
| His 1215 | - | expression tag |
| His 1216 | - | expression tag |
| His 1217 | - | expression tag |
| His 1218 | - | expression tag |
| His 1219 | - | expression tag |
| His 1220 | - | expression tag |
| His 1221 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 196805.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1322.9 | |
| All* | Total formula weight | 198128.9 |
