5ZKQ

Crystal structure of the human platelet-activating factor receptor in complex with ABT-491

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor	polymer	438	50127.5	2	UniProt (P25105) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (Human)	PAFr, Lysis protein, Lysozyme, Muramidase
2	A, B	4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide	non-polymer		479.5	2	Chemie (9EU)
3	A, B	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	7	Chemie (OLC)
4	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	B	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
6		water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 2 - 218 (UniProt: P25105)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Tyr 116	Phe 116	engineered mutation
Asp 169	Asn 169	engineered mutation

A, B: 1001 - 1010 (UniProt: P00720)
A, B: 1017 - 1117 (UniProt: P00720)

PDB	External Database	Details
Gly 1011	-	linker
Gly 1012	-	linker
Gly 1013	-	linker
Ser 1014	-	linker
Gly 1015	-	linker
Gly 1016	-	linker
Ala 1053	Cys 97	engineered mutation
Arg 1093	Ile 137	engineered mutation

A, B: 224 - 316 (UniProt: P25105)

PDB	External Database	Details
Asp 230	Ala 230	engineered mutation
Ala 234	Val 234	engineered mutation
Asn 289	Asp 289	engineered mutation
Glu 317	-	expression tag
Phe 318	-	expression tag
Leu 319	-	expression tag
Glu 320	-	expression tag
Val 321	-	expression tag
Leu 322	-	expression tag
Phe 323	-	expression tag
Gln 324	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	100255.1
Non-Polymers*	Number of molecules	17
	Total formula weight	4162.0
All*	Total formula weight	104417.1

*Water molecules are not included.