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5ZHX

Crystal structure of SmgGDS-558 and farnesylated RhoA complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DRap1 GTPase-GDP dissociation stimulator 1polymer48753418.94UniProt (P52306)
Pfam (PF00514)
In PDB
Homo sapiens (Human)Exchange factor smgGDS,SMG GDS protein,SMG P21 stimulatory GDP/GTP exchange protein
2e, f, g, hTransforming protein RhoApolymer19822168.54UniProt (P61586)
Pfam (PF00071)
In PDB
Homo sapiens (Human)Rho cDNA clone 12,h12
3e, f, g, hFARNESYLnon-polymer206.44Chemie (FAR)
Sequence modifications
A, B, C, D: 77 - 558 (UniProt: P52306)
PDBExternal DatabaseDetails
Gly 72-expression tag
Pro 73-expression tag
Leu 74-expression tag
Gly 75-expression tag
Ser 76-expression tag
e, f, g, h: 1 - 193 (UniProt: P61586)
PDBExternal DatabaseDetails
Gly -4-expression tag
Pro -3-expression tag
Leu -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
Ala 193Leu 193engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight302349.9
Non-Polymers*Number of molecules4
Total formula weight825.5
All*Total formula weight303175.4
*Water molecules are not included.

217705

数据于2024-03-27公开中

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