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5ZC9

Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AEukaryotic initiation factor 4A-Ipolymer39444901.41UniProt (P60842)
Pfam (PF00270)
Pfam (PF00271)
In PDB
Homo sapiens (Human)Eukaryotic translation initiation factor 4A-I,eIF4A-I,ATP-dependent RNA helicase eIF4A-1
2BRNA (5'-R(*AP*GP*AP*GP*AP*GP*AP*GP*AP*G)-3')polymer103327.11synthetic construct
3APHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21Chemie (ANP)
4AMAGNESIUM IONnon-polymer24.31Chemie (MG)
5B(1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamidenon-polymer505.61Chemie (RCG)
6waterwater18.0246Chemie (HOH)
Sequence modifications
A: 19 - 406 (UniProt: P60842)
PDBExternal DatabaseDetails
Gly 13-expression tag
Pro 14-expression tag
Gly 15-expression tag
Tyr 16-expression tag
Gln 17-expression tag
Asp 18-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight48228.5
Non-Polymers*Number of molecules3
Total formula weight1036.1
All*Total formula weight49264.6
*Water molecules are not included.

217705

數據於2024-03-27公開中

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