5YGI
Crystal structure of human FPPS in complex with an inhibitor THZ93
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Farnesyl pyrophosphate synthase | polymer | 348 | 40029.7 | 1 | UniProt (P14324) Pfam (PF00348) In PDB | Homo sapiens (Human) | FPS,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Geranyltranstransferase |
| 2 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | A | [[(4-hexoxypyridin-2-yl)amino]-phosphono-methyl]phosphonic acid | non-polymer | 368.3 | 1 | Chemie (T93) | |||
| 5 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40029.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 631.1 | |
| All* | Total formula weight | 40660.8 |
