5XF1
Structure of the Full-length glucagon class B G protein-coupled receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Glucagon receptor,Endolysin,Glucagon receptor | polymer | 574 | 65784.1 | 2 | UniProt (P47871) UniProt (D9IEF7) Pfam (PF02793) Pfam (PF00002) Pfam (PF00959) UniProt (by SIFTS) (P00720) In PDB | Homo sapiens (Human) | GL-R,Lysis protein,Lysozyme,Muramidase,GL-R |
| 2 | C, H | Antibody mAb1 Heavy chain | polymer | 231 | 24978.0 | 2 | Homo sapiens | ||
| 3 | D, L | Antibody mAb1 Light chain | polymer | 214 | 23263.8 | 2 | Homo sapiens | ||
| 4 | E, F, G, I, K | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 5 | J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ) | triacetyl-beta-chitotriose | ||
| 6 | A, B | 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide | non-polymer | 573.7 | 2 | Chemie (97V) | |||
| 7 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 256 (UniProt: P47871)
A, B: 1002 - 1161 (UniProt: D9IEF7)
A, B: 260 - 432 (UniProt: P47871)
| PDB | External Database | Details |
|---|---|---|
| Gly 24 | - | expression tag |
| Ala 25 | - | expression tag |
| Pro 26 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 1054 | Cys 54 | engineered mutation |
| Ala 1097 | Cys 97 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 433 | - | expression tag |
| Phe 434 | - | expression tag |
| Leu 435 | - | expression tag |
| Glu 436 | - | expression tag |
| Val 437 | - | expression tag |
| Leu 438 | - | expression tag |
| Phe 439 | - | expression tag |
| Gln 440 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 228051.7 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2749.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1368.5 | |
| All* | Total formula weight | 232169.8 |
