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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5OOM

Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A16S ribosomal RNApolymer1559500019.61GenBank (1025814679)Homo sapiens (Human)
2Bmitochondrial tRNAValpolymer6922022.11GenBank (1215733170)Homo sapiens (Human)
3D39S ribosomal protein L2, mitochondrialpolymer30533355.91UniProt (Q5T653)
Pfam (PF03947)
Pfam (PF00181)
In PDB		Homo sapiens (Human)MRP-L2,Mitochondrial large ribosomal subunit protein uL2m
4E39S ribosomal protein L3, mitochondrialpolymer34838689.61UniProt (P09001)
Pfam (PF00297)
In PDB		Homo sapiens (Human)MRP-L3,Mitochondrial large ribosomal subunit protein uL3m
5F39S ribosomal protein L4, mitochondrialpolymer31134970.21UniProt (Q9BYD3)
Pfam (PF00573)
In PDB		Homo sapiens (Human)MRP-L4,Mitochondrial large ribosomal subunit protein uL4m
6H39S ribosomal protein L9, mitochondrialpolymer26730296.41UniProt (Q9BYD2)
Pfam (PF01281)
In PDB		Homo sapiens (Human)MRP-L9,Mitochondrial large ribosomal subunit protein bL9m
7I39S ribosomal protein L10, mitochondrialpolymer26129322.51UniProt (Q7Z7H8)
Pfam (PF00466)
In PDB		Homo sapiens (Human)MRP-L10,39S ribosomal protein L8,mitochondrial,MRP-L8,Mitochondrial large ribosomal subunit protein uL10m
8J39S ribosomal protein L11, mitochondrialpolymer19220716.21UniProt (Q9Y3B7)
Pfam (PF03946)
Pfam (PF00298)
In PDB		Homo sapiens (Human)MRP-L11,Mitochondrial large ribosomal subunit protein uL11m
9K39S ribosomal protein L13, mitochondrialpolymer17820723.01UniProt (Q9BYD1)
Pfam (PF00572)
In PDB		Homo sapiens (Human)MRP-L13,Mitochondrial large ribosomal subunit protein uL13m
10L39S ribosomal protein L14, mitochondrialpolymer14515973.71UniProt (Q6P1L8)
Pfam (PF00238)
In PDB		Homo sapiens (Human)MRP-L14,39S ribosomal protein L32,mitochondrial,MRP-L32,Mitochondrial large ribosomal subunit protein uL14m
11M39S ribosomal protein L15, mitochondrialpolymer29633473.81UniProt (Q9P015)
Pfam (PF00828)
In PDB		Homo sapiens (Human)MRP-L15,Mitochondrial large ribosomal subunit protein uL15m
12N39S ribosomal protein L16, mitochondrialpolymer25128496.31UniProt (Q9NX20)
Pfam (PF00252)
In PDB		Homo sapiens (Human)MRP-L16,Mitochondrial large ribosomal subunit protein uL16m
13O39S ribosomal protein L17, mitochondrialpolymer17520083.31UniProt (Q9NRX2)
Pfam (PF01196)
In PDB		Homo sapiens (Human)MRP-L17,LYST-interacting protein 2,Mitochondrial large ribosomal subunit protein bL17m
14P39S ribosomal protein L18, mitochondrialpolymer18020607.61UniProt (Q9H0U6)
Pfam (PF00861)
In PDB		Homo sapiens (Human)MRP-L18,Mitochondrial large ribosomal subunit protein uL18m
15Q39S ribosomal protein L19, mitochondrialpolymer29233585.01UniProt (P49406)
Pfam (PF01245)
In PDB		Homo sapiens (Human)MRP-L19,39S ribosomal protein L15,mitochondrial,MRP-L15,Mitochondrial large ribosomal subunit protein bL19m
16R39S ribosomal protein L20, mitochondrialpolymer14917479.71UniProt (Q9BYC9)
Pfam (PF00453)
In PDB		Homo sapiens (Human)MRP-L20,Mitochondrial large ribosomal subunit protein bL20m
17S39S ribosomal protein L21, mitochondrialpolymer20522847.71UniProt (Q7Z2W9)
Pfam (PF00829)
In PDB		Homo sapiens (Human)MRP-L21,Mitochondrial large ribosomal subunit protein bL21m
18T39S ribosomal protein L22, mitochondrialpolymer20623683.71UniProt (Q9NWU5)
Pfam (PF00237)
In PDB		Homo sapiens (Human)MRP-L22,39S ribosomal protein L25,mitochondrial,MRP-L25,Mitochondrial large ribosomal subunit protein uL22m
19U39S ribosomal protein L23, mitochondrialpolymer15317807.21UniProt (Q16540)
Pfam (PF00276)
In PDB		Homo sapiens (Human)MRP-L23,L23 mitochondrial-related protein,Mitochondrial large ribosomal subunit protein uL23m,Ribosomal protein L23-like
20V39S ribosomal protein L24, mitochondrialpolymer21624953.91UniProt (Q96A35)
Pfam (PF00467)
Pfam (PF17136)
In PDB		Homo sapiens (Human)MRP-L24,Mitochondrial large ribosomal subunit protein uL24m
21W39S ribosomal protein L27, mitochondrialpolymer14816102.91UniProt (Q9P0M9)
Pfam (PF01016)
In PDB		Homo sapiens (Human)MRP-L27,Mitochondrial large ribosomal subunit protein bL27m
22X39S ribosomal protein L28, mitochondrialpolymer25630202.91UniProt (Q13084)
Pfam (PF00830)
In PDB		Homo sapiens (Human)MRP-L28,Melanoma antigen p15,Melanoma-associated antigen recognized by T-lymphocytes,Mitochondrial large ribosomal subunit protein bL28m
23Y39S ribosomal protein L47, mitochondrialpolymer25029508.51UniProt (Q9HD33)
Pfam (PF06984)
In PDB		Homo sapiens (Human)MRP-L47,Mitochondrial large ribosomal subunit protein uL29m,Nasopharyngeal carcinoma metastasis-related protein 1
24Z39S ribosomal protein L30, mitochondrialpolymer16118582.81UniProt (Q8TCC3)
Pfam (PF00327)
In PDB		Homo sapiens (Human)MRP-L30,39S ribosomal protein L28,mitochondrial,MRP-L28,Mitochondrial large ribosomal subunit protein uL30m
25039S ribosomal protein L32, mitochondrialpolymer18821437.81UniProt (Q9BYC8)
Pfam (PF01783)
In PDB		Homo sapiens (Human)MRP-L32,Mitochondrial large ribosomal subunit protein bL32m
26139S ribosomal protein L33, mitochondrialpolymer657635.21UniProt (O75394)
Pfam (PF00471)
In PDB		Homo sapiens (Human)MRP-L33,Mitochondrial large ribosomal subunit protein bL33m
27239S ribosomal protein L34, mitochondrialpolymer9210183.91UniProt (Q9BQ48)
Pfam (PF00468)
In PDB		Homo sapiens (Human)MRP-L34,Mitochondrial large ribosomal subunit protein bL34m
28339S ribosomal protein L35, mitochondrialpolymer18821558.51UniProt (Q9NZE8)
Pfam (PF01632)
In PDB		Homo sapiens (Human)MRP-L35,Mitochondrial large ribosomal subunit protein bL35m
29539S ribosomal protein L37, mitochondrialpolymer42348183.31UniProt (Q9BZE1)
Pfam (PF07147)
In PDB		Homo sapiens (Human)MRP-L37,39S ribosomal protein L2,mitochondrial,MRP-L2,Mitochondrial large ribosomal subunit protein mL37
30639S ribosomal protein L38, mitochondrialpolymer38044659.41UniProt (Q96DV4)
Pfam (PF01161)
In PDB		Homo sapiens (Human)MRP-L38,Mitochondrial large ribosomal subunit protein mL38
31739S ribosomal protein L39, mitochondrialpolymer33838764.81UniProt (Q9NYK5)
In PDB		Homo sapiens (Human)MRP-L39,39S ribosomal protein L5,mitochondrial,MRP-L5,Mitochondrial large ribosomal subunit protein mL39
32839S ribosomal protein L40, mitochondrialpolymer20624534.41UniProt (Q9NQ50)
Pfam (PF09812)
In PDB		Homo sapiens (Human)MRP-L40,Mitochondrial large ribosomal subunit protein mL40,Nuclear localization signal-containing protein deleted in velocardiofacial syndrome,Up-regulated in metastasis
33939S ribosomal protein L41, mitochondrialpolymer13715404.71UniProt (Q8IXM3)
Pfam (PF09809)
In PDB		Homo sapiens (Human)MRP-L41,39S ribosomal protein L27 homolog,Bcl-2-interacting mitochondrial ribosomal protein L41,Cell proliferation-inducing gene 3 protein,MRP-L27 homolog,Mitochondrial large ribosomal subunit protein mL41
34a39S ribosomal protein L42, mitochondrialpolymer14216691.21UniProt (Q9Y6G3)
Pfam (PF10210)
In PDB		Homo sapiens (Human)MRP-L42,39S ribosomal protein L31,mitochondrial,MRP-L31,Mitochondrial large ribosomal subunit protein mL42
35b39S ribosomal protein L43, mitochondrialpolymer21523457.81UniProt (Q8N983)
Pfam (PF05047)
In PDB		Homo sapiens (Human)MRP-L43,Mitochondrial large ribosomal subunit protein mL43,Mitochondrial ribosomal protein bMRP36a
36c39S ribosomal protein L44, mitochondrialpolymer33237583.31UniProt (Q9H9J2)
In PDB		Homo sapiens (Human)MRP-L44,Mitochondrial large ribosomal subunit protein mL44
37d39S ribosomal protein L45, mitochondrialpolymer30635402.91UniProt (Q9BRJ2)
Pfam (PF04280)
In PDB		Homo sapiens (Human)MRP-L45,Mitochondrial large ribosomal subunit protein mL45
38e39S ribosomal protein L46, mitochondrialpolymer27931748.11UniProt (Q9H2W6)
Pfam (PF11788)
In PDB		Homo sapiens (Human)MRP-L46,Mitochondrial large ribosomal subunit protein mL46,P2ECSL
39f39S ribosomal protein L48, mitochondrialpolymer21223970.81UniProt (Q96GC5)
Pfam (PF00338)
In PDB		Homo sapiens (Human)MRP-L48,Mitochondrial large ribosomal subunit protein mL48
40g39S ribosomal protein L49, mitochondrialpolymer16619225.01UniProt (Q13405)
Pfam (PF05046)
In PDB		Homo sapiens (Human)MRP-L49,Mitochondrial large ribosomal subunit protein mL49,Neighbor of FAU,NOF,Protein NOF1
41h39S ribosomal protein L50, mitochondrialpolymer15818349.91UniProt (Q8N5N7)
Pfam (PF10501)
In PDB		Homo sapiens (Human)MRP-L50,Mitochondrial large ribosomal subunit protein mL50
42i39S ribosomal protein L51, mitochondrialpolymer12815125.91UniProt (Q4U2R6)
Pfam (PF10244)
In PDB		Homo sapiens (Human)MRP-L51,Mitochondrial large ribosomal subunit protein mL51,bMRP-64,bMRP64
43j39S ribosomal protein L52, mitochondrialpolymer12313682.71UniProt (Q86TS9)
Pfam (PF18699)
In PDB		Homo sapiens (Human)MRP-L52,Mitochondrial large ribosomal subunit protein mL52
44k39S ribosomal protein L53, mitochondrialpolymer11212125.91UniProt (Q96EL3)
Pfam (PF10780)
In PDB		Homo sapiens (Human)MRP-L53,Mitochondrial large ribosomal subunit protein mL53
45l39S ribosomal protein L54, mitochondrialpolymer13815844.21UniProt (Q6P161)
Pfam (PF08561)
In PDB		Homo sapiens (Human)MRP-L54,Mitochondrial large ribosomal subunit protein mL54
46m39S ribosomal protein L55, mitochondrialpolymer12815160.41UniProt (Q7Z7F7)
Pfam (PF09776)
In PDB		Homo sapiens (Human)MRP-L55,Mitochondrial large ribosomal subunit protein bL31m,Mitochondrial large ribosomal subunit protein mL55
47oRibosomal protein 63, mitochondrialpolymer10212292.31UniProt (Q9BQC6)
Pfam (PF14978)
In PDB		Homo sapiens (Human)hMRP63,Mitochondrial large ribosomal subunit protein mL63,Mitochondrial ribosomal protein 63,Mitochondrial ribosomal protein L57
48pPeptidyl-tRNA hydrolase ICT1, mitochondrialpolymer20623674.21UniProt (Q14197)
Pfam (PF00472)
In PDB		Homo sapiens (Human)39S ribosomal protein L58,mitochondrial,MRP-L58,Digestion substraction 1,DS-1,Immature colon carcinoma transcript 1 protein,Mitochondrial large ribosomal subunit protein mL62
49qGrowth arrest and DNA damage-inducible proteins-interacting protein 1polymer22225426.91UniProt (Q8TAE8)
Pfam (PF10147)
In PDB		Homo sapiens (Human)39S ribosomal protein L59,mitochondrial,MRP-L59,CKII beta-associating protein,CR6-interacting factor 1,CRIF1,Mitochondrial large ribosomal subunit protein mL64,Papillomavirus L2-interacting nuclear protein 1,PLINP-1,p53-responsive gene 6 protein
50r39S ribosomal protein S18a, mitochondrialpolymer19622224.11UniProt (Q9NVS2)
Pfam (PF01084)
In PDB		Homo sapiens (Human)S18mt-a,39S ribosomal protein S18-3,mitochondrial,MRP-S18-3,Mitochondrial large ribosomal subunit protein bS18a,Mitochondrial large ribosomal subunit protein mL66
51s39S ribosomal protein S30, mitochondrialpolymer43950429.61UniProt (Q9NP92)
Pfam (PF07147)
In PDB		Homo sapiens (Human)S30mt,Mitochondrial large ribosomal subunit protein mL65,Mitochondrial large ribosomal subunit protein mS30,Programmed cell death protein 9
52tUnknown protein or protein extensionpolymer282401.01Homo sapiens (Human)
53uMitochondrial assembly of ribosomal large subunit protein 1polymer23426203.11UniProt (Q96EH3)
Pfam (PF02410)
In PDB		Homo sapiens (Human)
54vMIEF1 upstream open reading frame proteinpolymer708460.81UniProt (L0R8F8)
Pfam (PF05347)
In PDB		Homo sapiens (Human)
55wAcyl carrier protein, mitochondrialpolymer15617434.31UniProt (O14561)
Pfam (PF00550)
In PDB		Homo sapiens (Human)ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit
56A, g, WMAGNESIUM IONnon-polymer24.349Chemie (MG)
570, IZINC IONnon-polymer65.42Chemie (ZN)
58v4'-PHOSPHOPANTETHEINEnon-polymer358.31Chemie (PNS)
Sequence modifications
A: 1671 - 3229 (GenBank: 1025814679)
PDBExternal DatabaseDetails
U 3107Unk 3109conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains55
Total formula weight1782780.8
Non-Polymers*Number of molecules52
Total formula weight1680.1
All*Total formula weight1784460.9
*Water molecules are not included.

218500

數據於2024-04-17公開中

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