5MAH
Crystal structure of MELK in complex with an inhibitor
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A | Maternal embryonic leucine zipper kinase | polymer | 347 | 40220.5 | 1 | UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) In PDB | Homo sapiens (Human) | hMELK,Protein kinase Eg3,pEg3 kinase,Protein kinase PK38,hPK38,Tyrosine-protein kinase MELK |
| 2 | A | ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | non-polymer | 510.5 | 1 | Chemie (7KD) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | water | water | 18.0 | 96 | Chemie (HOH) |
配列変更
A: 2 - 340 (UniProt: Q14680)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 1 |
| 化学式量合計 | 40220.5 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 5 |
| 化学式量合計 | 684.0 | |
| 全て* | 化学式量合計 | 40904.6 |
