5M6R

Human porphobilinogen deaminase in complex with reaction intermediate

エンティティ

Entity ID	鎖名	説明	種類	鎖長	化学式量	分子数	データベース名(アクセス番号)	由来する生物種	エンティティの一般名
1	A, B	Porphobilinogen deaminase	polymer	389	42718.7	2	UniProt (P08397) Pfam (PF01379) Pfam (PF03900) In PDB	Homo sapiens (Human)	PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase
2	A, B	3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid	non-polymer		838.8	2	Chemie (7J8)
3	A, B	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
4	A	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
5		water	water		18.0	23	Chemie (HOH)

配列変更

A, B: 1 - 361 (UniProt: P08397)

PDB	外部データベース	詳細
Met -27	-	initiating methionine
Lys -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
Pro -19	-	expression tag
Met -18	-	expression tag
Ser -17	-	expression tag
Asp -16	-	expression tag
Tyr -15	-	expression tag
Asp -14	-	expression tag
Ile -13	-	expression tag
Pro -12	-	expression tag
Thr -11	-	expression tag
Thr -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag

非対称単位の内容

タンパク質・ 核酸鎖	鎖の数	2
	化学式量合計	85437.4
タンパク質・ 核酸・ 糖鎖以外*	分子数	6
	化学式量合計	2200.8
全て*	化学式量合計	87638.3

*水分子は含んでいません