5AAB

Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ALK TYROSINE KINASE RECEPTOR	polymer	327	37003.4	1	UniProt (Q9UM73) Pfam (PF07714) In PDB	HOMO SAPIENS (HUMAN)	ANAPLASTIC LYMPHOMA KINASE
2	A	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine	non-polymer		450.3	1	Chemie (VGH)
3		water	water		18.0	192	Chemie (HOH)

Sequence modifications

A: 1093 - 1411 (UniProt: Q9UM73)

PDB	External Database	Details
Met 1085	-	expression tag
Ala 1086	-	expression tag
His 1087	-	expression tag
His 1088	-	expression tag
His 1089	-	expression tag
His 1090	-	expression tag
His 1091	-	expression tag
His 1092	-	expression tag
Tyr 1156	Cys 1156	engineered mutation
Phe 1198	Leu 1198	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37003.4
Non-Polymers*	Number of molecules	1
	Total formula weight	450.3
All*	Total formula weight	37453.7

*Water molecules are not included.