4WUY
Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A | N-lysine methyltransferase SMYD2 | polymer | 441 | 50775.1 | 1 | UniProt (Q9NRG4) Pfam (PF00856) Pfam (PF01753) In PDB | Homo sapiens (Human) | HSKM-B,Histone methyltransferase SMYD2,Lysine N-methyltransferase 3C,SET and MYND domain-containing protein 2 |
| 2 | A | 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide | non-polymer | 574.8 | 1 | Chemie (3UJ) | |||
| 3 | A | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | A | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | water | water | 18.0 | 430 | Chemie (HOH) |
配列変更
A: 1 - 433 (UniProt: Q9NRG4)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Glu 434 | - | expression tag |
| Gly 435 | - | expression tag |
| His 436 | - | expression tag |
| His 437 | - | expression tag |
| His 438 | - | expression tag |
| His 439 | - | expression tag |
| His 440 | - | expression tag |
| His 441 | - | expression tag |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 1 |
| 化学式量合計 | 50775.1 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 9 |
| 化学式量合計 | 1497.1 | |
| 全て* | 化学式量合計 | 52272.2 |
