4DFR
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
Replaces: 2DFREntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | DIHYDROFOLATE REDUCTASE | polymer | 159 | 18020.4 | 2 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli | |
| 2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | A, B | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
| 4 | B | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | water | water | 18.0 | 428 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Asp 37 | Asn 37 | conflict |
| Lys 154 | Glu 154 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36040.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1019.9 | |
| All* | Total formula weight | 37060.6 |
