4A7C
Crystal structure of PIM1 kinase with ETP46546
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 | polymer | 308 | 35445.1 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | PIM1 |
| 2 | A | N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethyloxy)phenyl]-[1,2,3]triazolo[4,5-b]pyridin-5-amine | non-polymer | 392.4 | 1 | Chemie (E46) | |||
| 3 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A: 30 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Met 6 | - | expression tag |
| Gly 7 | - | expression tag |
| Ser 8 | - | expression tag |
| Ser 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Val 21 | - | expression tag |
| Leu 22 | - | expression tag |
| Phe 23 | - | expression tag |
| Gln 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Pro 26 | - | expression tag |
| His 27 | - | expression tag |
| Met 28 | - | expression tag |
| Lys 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35445.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 520.5 | |
| All* | Total formula weight | 35965.6 |
