4A69
Structure of HDAC3 bound to corepressor and inositol tetraphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | HISTONE DEACETYLASE 3, | polymer | 376 | 42916.5 | 2 | UniProt (O15379) Pfam (PF00850) In PDB | HOMO SAPIENS (HUMAN) | HD3, RPD3-2, SMAP45, HDAC3 |
| 2 | C, D | NUCLEAR RECEPTOR COREPRESSOR 2 | polymer | 94 | 11309.2 | 2 | UniProt (Q9Y618) Pfam (PF00249) In PDB | HOMO SAPIENS (HUMAN) | N-COR2, CTG REPEAT PROTEIN 26, SMAP270, SILENCING MEDIATOR OF RETINOIC ACID AND THYROID HORMONE RECEPTOR, SMRT, T3 RECEPTOR-ASSOCIATING FACTOR, TRAC, THYROID-\,RETINOIC-ACID-RECEPTOR-ASSOCIATED COREPRESSOR |
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | A, B | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 6 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | C, D | D-MYO INOSITOL 1,4,5,6 TETRAKISPHOSPHATE | non-polymer | 500.1 | 2 | Chemie (I0P) | |||
| 8 | water | water | 18.0 | 347 | Chemie (HOH) |
Sequence modifications
C, D: 389 - 480 (UniProt: Q9Y618)
| PDB | External Database | Details |
|---|---|---|
| Gly 387 | - | expression tag |
| Ala 388 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 108451.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1773.8 | |
| All* | Total formula weight | 110225.3 |
