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3OFS

Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D, E...ADP-ribosyl cyclase 1polymer25729754.76UniProt (P28907)
Pfam (PF02267)
In PDB
Homo sapiens (human)CD38, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10
2A, B, C, D, E...[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphatenon-polymer545.36Chemie (AVU)
3waterwater18.0392Chemie (HOH)
Sequence modifications
A, B, C, D, E, F: 46 - 300 (UniProt: P28907)
PDBExternal DatabaseDetails
Glu 44-expression tag
Phe 45-expression tag
Thr 49Gln 49engineered mutation
Asp 100Asn 100engineered mutation
Ala 146Glu 146engineered mutation
Asp 164Asn 164engineered mutation
Asp 209Asn 209engineered mutation
Asp 219Asn 219engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight178528.2
Non-Polymers*Number of molecules6
Total formula weight3271.8
All*Total formula weight181800.1
*Water molecules are not included.

217705

数据于2024-03-27公开中

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