3DR1
Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vitamin D3 receptor A | polymer | 302 | 34060.7 | 1 | UniProt (Q9PTN2) Pfam (PF00104) In PDB | Danio rerio (zebra fish) | VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A |
| 2 | B | SRC-1 (LXXLL motif) from Nuclear receptor coactivator 1 | polymer | 15 | 1776.1 | 1 | UniProt (Q15788) In PDB | Homo sapiens | NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52 |
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol | non-polymer | 482.5 | 1 | Chemie (C5D) | |||
| 5 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 156 - 453 (UniProt: Q9PTN2)
| PDB | External Database | Details |
|---|---|---|
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
| His 154 | - | expression tag |
| Met 155 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35836.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 506.8 | |
| All* | Total formula weight | 36343.5 |
