3D8C

Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hypoxia-inducible factor 1 alpha inhibitor	polymer	349	40270.2	1	UniProt (Q9NWT6) Pfam (PF13621) In PDB	Homo sapiens (human)	Hypoxia-inducible factor asparagine hydroxylase, Factor inhibiting HIF-1, FIH-1
2	B	HYPOXIA-INDUCIBLE FACTOR 1 ALPHA	polymer	19	2051.2	1			HIF-1 ALPHA, HIF1 ALPHA, ARNT- INTERACTING PROTEIN, MEMBER OF PAS PROTEIN 1, MOP1
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	A	2-OXOGLUTARIC ACID	non-polymer		146.1	1	Chemie (AKG)
6	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7		water	water		18.0	223	Chemie (HOH)

Sequence modifications

A: 11 - 349 (UniProt: Q9NWT6)

PDB	External Database	Details
Met 1	-	expression tag
Ala 2	-	expression tag
Ala 3	-	expression tag
Thr 4	-	expression tag
Ala 5	-	expression tag
Ala 6	-	expression tag
Glu 7	-	expression tag
Ala 8	-	expression tag
Val 9	-	expression tag
Ala 10	-	expression tag
Gly 201	Asp 201	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42321.4
Non-Polymers*	Number of molecules	5
	Total formula weight	495.7
All*	Total formula weight	42817.2

*Water molecules are not included.