3CF6
Structure of Epac2 in complex with cyclic-AMP and Rap
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | Rap guanine nucleotide exchange factor (GEF) 4 | polymer | 694 | 79277.8 | 1 | UniProt (A2ASW3) In PDB | Mus musculus (mouse) | |
| 2 | R | Ras-related protein Rap-1b | polymer | 167 | 19020.5 | 1 | UniProt (P61224) Pfam (PF00071) In PDB | Homo sapiens (human) | GTP-binding protein smg p21B, Rap1B |
| 3 | E | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL | non-polymer | 345.3 | 2 | Chemie (SP1) | |||
| 4 | R | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
E: 306 - 993 (UniProt: A2ASW3)
| PDB | External Database | Details |
|---|---|---|
| Gly 300 | - | expression tag |
| Ser 301 | - | expression tag |
| Pro 302 | - | expression tag |
| Glu 303 | - | expression tag |
| Ser 304 | - | expression tag |
| Phe 305 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98298.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 786.6 | |
| All* | Total formula weight | 99085.0 |
