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3ACJ

Crystal structure of imidazo pyrimidine derivative bound to the kinase domain of human LCK, (Auto-phosphorylated on TYR394)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AProto-oncogene tyrosine-protein kinase LCKpolymer28533065.61UniProt (P06239)
Pfam (PF07714)
In PDB
Homo sapiens (human)LYMPHOCYTE KINASE, LCK, Lymphocyte cell-specific protein-tyrosine kinase, p56-LCK, LSK, T cell-specific protein-tyrosine kinase
2ASULFATE IONnon-polymer96.12Chemie (SO4)
3ADIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
4A7-(3,4-dimethoxyphenyl)-5-(ethylsulfanyl)imidazo[1,2-c]pyrimidinenon-polymer315.41Chemie (KSS)
5waterwater18.0200Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight33065.6
Non-Polymers*Number of molecules4
Total formula weight585.6
All*Total formula weight33651.3
*Water molecules are not included.

217705

건을2024-03-27부터공개중

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