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2VJ9

Human BACE-1 in complex with N-((1S,2R)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ABETA-SECRETASE 1polymer39243761.31UniProt (P56817)
Pfam (PF00026)
In PDB
HOMO SAPIENS (HUMAN)BETA-SITE APP CLEAVING ENZYME 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BACE-1
2AN-[(1S,2R)-1-benzyl-3-(cyclohexylamino)-2-hydroxypropyl]-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamidenon-polymer492.71Chemie (VG7)
3waterwater18.0351Chemie (HOH)
Sequence modifications
A: 61 - 452 (UniProt: P56817)
PDBExternal DatabaseDetails
Gln 153Asn 153engineered mutation
Gln 172Asn 172engineered mutation
Gln 223Asn 223engineered mutation
Gln 354Asn 354engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight43761.3
Non-Polymers*Number of molecules1
Total formula weight492.7
All*Total formula weight44254.0
*Water molecules are not included.

217705

數據於2024-03-27公開中

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