2V8Q

Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1	polymer	157	17635.8	1	UniProt (P54645) Pfam (PF16579) In PDB	RATTUS NORVEGICUS (RAT)	AMP-ACTIVATED PROTEIN KINASE, AMPK ALPHA-1 CHAIN
2	B	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2	polymer	87	10040.8	1	UniProt (O43741) Pfam (PF04739) In PDB	HOMO SAPIENS (HUMAN)	AMP-ACTIVATED PROTEIN KINASE, AMPK BETA-2 CHAIN
3	E	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1	polymer	330	37434.1	1	UniProt (P80385) Pfam (PF00571) In PDB	RATTUS NORVEGICUS (RAT)	AMP-ACTIVATED PROTEIN KINASE, AMPK GAMMA-1 CHAIN, AMPKG
4	E	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	3	Chemie (AMP)
5		water	water		18.0	428	Chemie (HOH)

Sequence modifications

A: 392 - 395 (PDB: 2V8Q)
A: 396 - 548 (UniProt: P54645)
B: 186 - 186 (PDB: 2V8Q)
B: 187 - 272 (UniProt: O43741)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	65110.7
Non-Polymers*	Number of molecules	3
	Total formula weight	1041.7
All*	Total formula weight	66152.4

*Water molecules are not included.