2V7A

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1	polymer	286	33142.8	2	UniProt (P00519) Pfam (PF07714) In PDB	HOMO SAPIENS (HUMAN)	ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, P150, C-ABL
2	A, B	N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE	non-polymer		474.6	2	Chemie (627)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4		water	water		18.0	166	Chemie (HOH)

Sequence modifications

A, B: 227 - 228 (PDB: 2V7A)
A, B: 229 - 512 (UniProt: P00519)

PDB	External Database	Details
Ile 315	Thr 315	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66285.6
Non-Polymers*	Number of molecules	4
	Total formula weight	997.7
All*	Total formula weight	67283.3

*Water molecules are not included.