2OC8
Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A, C | Hepatitis C virus | polymer | 200 | 21233.2 | 2 | UniProt (Q9ELS8) Pfam (PF02907) UniProt (by SIFTS) (P27958) In PDB | Hepatitis C virus | |
| 2 | B, D | Hepatitis C virus | polymer | 23 | 2394.0 | 2 | UniProt (Q9QP06) Pfam (PF01006) UniProt (by SIFTS) (P27958) In PDB | ||
| 3 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 5 | A | boceprevir (bound form) | non-polymer | 521.7 | 1 | Chemie (U5G) | |||
| 6 | water | water | 18.0 | 138 | Chemie (HOH) |
配列変更
A, C: 1 - 181 (UniProt: Q9ELS8)
B, D: 21 - 39 (UniProt: Q9QP06)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Met -10 | - | cloning artifact |
| Ala -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| Met -7 | - | cloning artifact |
| Thr -6 | - | cloning artifact |
| Gly -5 | - | cloning artifact |
| Gly -4 | - | cloning artifact |
| Gln -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Met -1 | - | cloning artifact |
| Gly 0 | - | cloning artifact |
| Arg 119 | Gln 1145 | conflict |
| Gly 182 | - | cloning artifact |
| Ser 183 | - | cloning artifact |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Lys 19 | - | cloning artifact |
| Lys 20 | - | cloning artifact |
| Lys 40 | - | cloning artifact |
| Lys 41 | - | cloning artifact |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 4 |
| 化学式量合計 | 47254.5 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 4 |
| 化学式量合計 | 730.6 | |
| 全て* | 化学式量合計 | 47985.2 |
