2IPJ

Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
A, BAldo-keto reductase family 1 member C2polymer32136447.92
UniProt (P52895)
Pfam (PF00248)
Homo sapiens (human)@PDBjTrans-1,2- dihydrobenzene-1,2-diol dehydrogenase, Type III 3- alpha-hydroxysteroid dehydrogenase, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Dihydrodiol dehydrogenase 2, DD2
SULFATE IONnon-polymer96.13
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.42
(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONEnon-polymer288.42
BETA-MERCAPTOETHANOLnon-polymer78.13
1,2-ETHANEDIOLnon-polymer62.17
waterwater18.0613

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains2
Total molecular weight72895.8
Non-Polymers*Number of molecules17
Total molecular weight3020.7
All*Total molecular weight75916.5
*Water molecules are not included.