2IPJ
Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A, B | Aldo-keto reductase family 1 member C2 | polymer | 321 | 36447.9 | 2 | UniProt (P52895) Pfam (PF00248) In PDB | Homo sapiens (human) | Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase, Type III 3- alpha-hydroxysteroid dehydrogenase, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Dihydrodiol dehydrogenase 2, DD2 |
| 2 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 4 | A, B | (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE | non-polymer | 288.4 | 2 | Chemie (FFA) | |||
| 5 | A, B | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 3 | Chemie (BME) | |||
| 6 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 7 | water | water | 18.0 | 613 | Chemie (HOH) |
配列変更
A, B: 3 - 323 (UniProt: P52895)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Ala 24 | Tyr 24 | conflict |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 2 |
| 化学式量合計 | 72895.8 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 17 |
| 化学式量合計 | 3020.7 | |
| 全て* | 化学式量合計 | 75916.5 |
