2HBH
Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vitamin D receptor | polymer | 302 | 34060.7 | 1 | UniProt (Q9PTN2) Pfam (PF00104) In PDB | Danio rerio (zebrafish) | |
| 2 | B | SRC-1 from Nuclear receptor coactivator 1 | polymer | 15 | 1776.1 | 1 | UniProt (Q15788) In PDB | Homo sapiens | NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, NY-REN-52 antigen |
| 3 | A | 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) | non-polymer | 394.5 | 1 | Chemie (XE4) | |||
| 4 | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 156 - 453 (UniProt: Q9PTN2)
| PDB | External Database | Details |
|---|---|---|
| Gly 152 | - | cloning artifact |
| Ser 153 | - | cloning artifact |
| His 154 | - | cloning artifact |
| Met 155 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35836.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 394.5 | |
| All* | Total formula weight | 36231.3 |
