2FHH
Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, D, F, I... | 20S proteasome, alpha and beta subunits | polymer | 251 | 27199.3 | 14 | GenBank (76783992) Pfam (PF00227) UniProt (by SIFTS) (P9WHU1) In PDB | Mycobacterium tuberculosis | |
2 | H, C, E, G, J... | proteasome, beta subunit | polymer | 240 | 25274.3 | 14 | GenBank (13881852) Pfam (PF00227) UniProt (by SIFTS) (P9WHT9) In PDB | Mycobacterium tuberculosis | |
3 | H, C, E, G, J... | (1R)-3-METHYL-1-{[N-(MORPHOLIN-4-YLCARBONYL)-3-(1-NAPHTHYL)-D-ALANYL]AMINO}BUTYLBORONIC ACID | non-polymer | 441.3 | 14 | Chemie (M1N) | |||
4 | water | water | 18.0 | 321 | Chemie (HOH) |
Sequence modifications
A, B, D, F, I, K, M, O, Q, S, U, W, Y, 1: 2 - 248 (GenBank: 76783992)
H, C, E, G, J, L, N, P, R, T, V, X, Z, 2: 301 - 534 (GenBank: 13881852)
PDB | External Database | Details |
---|---|---|
Met -2 | - | initiating methionine |
Asn -1 | - | cloning artifact |
Ser 0 | - | cloning artifact |
Ser 1 | - | cloning artifact |
PDB | External Database | Details |
---|---|---|
His 535 | - | expression tag |
His 536 | - | expression tag |
His 537 | - | expression tag |
His 538 | - | expression tag |
His 539 | - | expression tag |
His 540 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 28 |
Total formula weight | 734629.9 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 6178.6 | |
All* | Total formula weight | 740808.4 |