2F9V
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A, C | NS3 protease/helicase | polymer | 201 | 21290.3 | 2 | GenBank (28921568) Pfam (PF02907) UniProt (by SIFTS) (P27958) In PDB | Hepatitis C virus | |
| 2 | B, D | polyprotein | polymer | 23 | 2394.0 | 2 | GenBank (51039195) Pfam (PF01006) UniProt (by SIFTS) (P27958) In PDB | ||
| 3 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A | (2S,8R,9S,15S)-15-CYCLOHEXYL-9,12-BIS(CYCLOPROPYLMETHYL)-8-HYDROXY-20-METHYL-4,7,11,14,17-PENTAOXO-2-PHENYL-18-OXA-3,6,10,12,13,16-HEXAAZAHENICOSAN-1-OIC ACID | non-polymer | 700.8 | 1 | Chemie (BN6) | |||
| 5 | water | water | 18.0 | 132 | Chemie (HOH) |
配列変更
A, C: -11 - 189 (GenBank: 28921568)
B, D: 19 - 41 (GenBank: 51039195)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Met -11 | - | cloning artifact |
| Gly -10 | - | cloning artifact |
| Ala -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| Met -7 | - | cloning artifact |
| Thr -6 | - | cloning artifact |
| Gly -5 | - | cloning artifact |
| Gly -4 | - | cloning artifact |
| Gln -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Met -1 | - | cloning artifact |
| Gly 0 | - | cloning artifact |
| Gly 182 | - | cloning artifact |
| Ser 183 | - | cloning artifact |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Lys 19 | - | cloning artifact |
| Lys 20 | - | cloning artifact |
| Ser 22 | Cys 576 | engineered mutation |
| Lys 40 | - | cloning artifact |
| Lys 41 | - | cloning artifact |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 4 |
| 化学式量合計 | 47368.6 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 3 |
| 化学式量合計 | 831.6 | |
| 全て* | 化学式量合計 | 48200.3 |
