2BE5
Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, K, L | DNA-directed RNA polymerase alpha chain | polymer | 315 | 35056.2 | 4 | UniProt (Q9Z9H6) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) UniProt (by SIFTS) (Q5SHR6) In PDB | Thermus thermophilus | RNAP alpha subunit, Transcriptase alpha chain, RNA polymerase alpha subunit |
| 2 | C, M | DNA-directed RNA polymerase beta chain | polymer | 1119 | 125436.5 | 2 | UniProt (Q8RQE9) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) In PDB | Thermus thermophilus | RNAP beta subunit, Transcriptase beta chain, RNA polymerase beta subunit |
| 3 | D, N | DNA-directed RNA polymerase beta' chain | polymer | 1524 | 170997.4 | 2 | UniProt (Q8RQE8) Pfam (PF04997) Pfam (PF21668) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) In PDB | Thermus thermophilus | RNAP beta' subunit, Transcriptase beta' chain, RNA polymerase beta' subunit |
| 4 | E, O | RNA polymerase omega chain | polymer | 99 | 11521.2 | 2 | UniProt (Q8RQE7) Pfam (PF01192) In PDB | Thermus thermophilus | |
| 5 | F, P | RNA polymerase sigma factor rpoD | polymer | 423 | 48568.0 | 2 | UniProt (Q5SKW1) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) In PDB | Thermus thermophilus | |
| 6 | C, D, N | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 7 | D, N | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 8 | D, N | TAGETITOXIN | non-polymer | 416.3 | 2 | Chemie (TGT) | |||
| 9 | water | water | 18.0 | 8184 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 853271.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1191.5 | |
| All* | Total formula weight | 854462.4 |
