2AQB

Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	3-oxoacyl-[acyl-carrier-protein] synthase I	polymer	406	42656.2	4	UniProt (P0A953) Pfam (PF00109) Pfam (PF02801) In PDB	Escherichia coli	Beta- ketoacyl-ACP synthase I, KAS I
2	A, B, D	(5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE	non-polymer		196.3	3	Chemie (TL6)
3		water	water		18.0	537	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170624.8
Non-Polymers*	Number of molecules	3
	Total formula weight	588.8
All*	Total formula weight	171213.6

*Water molecules are not included.