2A4Q
HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound.
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A, C | NS3 protease/helicase' | polymer | 200 | 21233.2 | 2 | UniProt (Q91RS4) Pfam (PF02907) In PDB | Hepatitis C virus | |
| 2 | B, D | NS4a peptide | polymer | 23 | 2394.0 | 2 | UniProt (O39914) Pfam (PF01006) In PDB | ||
| 3 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 5 | A | (2R)-({N-[(3S)-3-({[(3S,6S)-6-CYCLOHEXYL-5,8-DIOXO-4,7-DIAZABICYCLO[14.3.1]ICOSA-1(20),16,18-TRIEN-3-YL]CARBONYL}AMINO)-2-OXOHEXANOYL]GLYCYL}AMINO)(PHENYL)ACETIC ACID | non-polymer | 745.9 | 1 | Chemie (FNH) | |||
| 6 | water | water | 18.0 | 169 | Chemie (HOH) |
配列変更
A, C: 1 - 181 (UniProt: Q91RS4)
B, D: 21 - 39 (UniProt: O39914)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Met -10 | - | cloning artifact |
| Ala -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| Met -7 | - | cloning artifact |
| Thr -6 | - | cloning artifact |
| Gly -5 | - | cloning artifact |
| Gly -4 | - | cloning artifact |
| Gln -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Met -1 | - | cloning artifact |
| Gly 0 | - | cloning artifact |
| Gly 182 | - | cloning artifact |
| Ser 183 | - | cloning artifact |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Lys 19 | - | cloning artifact |
| Lys 20 | - | cloning artifact |
| Ser 22 | Cys 576 | engineered mutation |
| Lys 40 | - | cloning artifact |
| Lys 41 | - | cloning artifact |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 4 |
| 化学式量合計 | 47254.5 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 4 |
| 化学式量合計 | 954.9 | |
| 全て* | 化学式量合計 | 48209.4 |
