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1PJ2

Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor NADH, Mn++, and allosteric activator fumarate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DNAD-dependent malic enzyme, mitochondrialpolymer56463893.24UniProt (P23368)
Pfam (PF00390)
Pfam (PF03949)
In PDB
Homo sapiens (human)NAD-ME, Malic enzyme 2
2A, B, C, D(2S)-2-hydroxybutanedioic acidnon-polymer134.14Chemie (LMR)
3A, B, C, DMANGANESE (II) IONnon-polymer54.94Chemie (MN)
4A, B, C, D1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDEnon-polymer665.48Chemie (NAI)
5A, B, C, DFUMARIC ACIDnon-polymer116.14Chemie (FUM)
6waterwater18.0748Chemie (HOH)
Sequence modifications
A, B, C, D: 21 - 584 (UniProt: P23368)
PDBExternal DatabaseDetails
Mse 29Met 29modified residue
Mse 38Met 38modified residue
Mse 47Met 47modified residue
Mse 75Met 75modified residue
Mse 86Met 86modified residue
Mse 108Met 108modified residue
Mse 177Met 177modified residue
Mse 219Met 219modified residue
Mse 239Met 239modified residue
Mse 325Met 325modified residue
Mse 327Met 327modified residue
Mse 343Met 343modified residue
Mse 407Met 407modified residue
Mse 539Met 539modified residue
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight255572.7
Non-Polymers*Number of molecules20
Total formula weight6543.9
All*Total formula weight262116.6
*Water molecules are not included.

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数据于2024-03-27公开中

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