1OIU

Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	CELL DIVISION PROTEIN KINASE 2	polymer	302	34354.8	2	UniProt (P24941) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	P33 PROTEIN KINASE, CDK2
2	B, D	CYCLIN A2	polymer	260	29884.6	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB	HOMO SAPIENS (HUMAN)	CYCLIN A, CCNA2, CCNA, CCN1
3	A, C	3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE	non-polymer		402.5	2	Chemie (N76)
4	B, D	MONOTHIOGLYCEROL	non-polymer		108.2	2	Chemie (SGM)
5	B	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6		water	water		18.0	646	Chemie (HOH)

Sequence modifications

A, C: -3 - 0 (PDB: 1OIU)
A, C: 1 - 298 (UniProt: P24941)
B, D: 173 - 173 (PDB: 1OIU)
B, D: 174 - 432 (UniProt: P20248)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	128478.8
Non-Polymers*	Number of molecules	5
	Total formula weight	1045.6
All*	Total formula weight	129524.3

*Water molecules are not included.