1MCW

THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY

エンティティ

Entity ID	鎖名	説明	種類	鎖長	化学式量	分子数	データベース名(アクセス番号)	由来する生物種	エンティティの一般名
1	W	IMMUNOGLOBULIN WEIR (LIGHT CHAIN)	polymer	216	22911.4	1	PIR (S25758)	Homo sapiens (human)
2	M	IMMUNOGLOBULIN MCG (LIGHT CHAIN)	polymer	216	22833.1	1	PIR (S14675) Pfam (PF07686) UniProt (by SIFTS) (P01709) In PDB	Homo sapiens (human)

配列変更

W: 2 - 215 (PIR: S25758)

PDB	外部データベース	詳細
Val 20	Ile 39	conflict
Ala 23	Thr 42	conflict
His 25	Ser 44	conflict
Thr 26	Ser 45	conflict
Ala 30	Gly 49	conflict
Asp 31	Gly 50	conflict
Ser 32	Tyr 51	conflict
Ser 34	Tyr 53	conflict
Ile 35	Val 54	conflict
Phe 38	Tyr 57	conflict
Asp 43	Gly 62	conflict
Leu 49	Met 68	conflict
Ala 52	Asp 71	conflict
Phe 55	Asn 74	conflict
Ile 60	Val 79	conflict
Pro 61	Ser 80	conflict
Leu 62	Asn 81	conflict
Leu 81	Gln 100	conflict
Asp 83	Glu 102	conflict
Phe 89	Tyr 108	conflict
Met 91	Thr 110	conflict
Tyr 93	Lys 112	conflict
Leu 94	Thr 113	conflict
Asp 96	-	insertion
Ala 97	Ser 115	conflict
-	Tyr 118	deletion
Ser 103	Thr 122	conflict
Thr 108	Ser 127	conflict
Arg 111	Gly 130	conflict
Glu 160	Lys 179	conflict

M: 2 - 216 (PIR: S14675)

PDB	外部データベース	詳細
Ile 20	Phe 39	conflict
Thr 23	Ser 42	conflict
Val 29	Ile 48	conflict
Gly 31	Asn 50	conflict
Gln 39	Arg 58	conflict
Ala 42	Pro 61	conflict
Val 48	Leu 67	conflict
Ile 49	Met 68	conflict
Asn 54	Thr 73	conflict
Asp 62	Asn 81	conflict
Glu 94	Ala 113	conflict
Asp 97	Asn 116	conflict
Asn 98	Ser 117	conflict
Phe 99	Leu 118	conflict
Val 100	Ile 119	conflict
Thr 103	Gly 122	conflict
Lys 106	Arg 125	conflict
Val 107	Leu 126	conflict
Asn 116	Ala 135	conflict
Thr 118	Ser 137	conflict
Gly 156	Ser 175	conflict
Lys 167	Thr 186	conflict

非対称単位の内容

タンパク質・ 核酸鎖	鎖の数	2
	化学式量合計	45744.5
全て*	化学式量合計	45744.5

*水分子は含んでいません