1H08

CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CELL DIVISION PROTEIN KINASE 2	polymer	299	34002.5	1	UniProt (P24941) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	P33 PROTEIN KINASE
2	A	(2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL	non-polymer		458.4	1	Chemie (BYP)
3	A	(2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL	non-polymer		458.4	1	Chemie (BWP)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	179	Chemie (HOH)

Sequence modifications

A: 0 - 0 (PDB: 1H08)
A: 1 - 298 (UniProt: P24941)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34002.5
Non-Polymers*	Number of molecules	3
	Total formula weight	1008.8
All*	Total formula weight	35011.3

*Water molecules are not included.