1FB7
CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | HIV-1 PROTEASE | polymer | 99 | 10849.8 | 1 | UniProt (Q72874) Pfam (PF00077) UniProt (by SIFTS) (P04585) In PDB | Human immunodeficiency virus 1 | |
| 2 | A | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide | non-polymer | 670.8 | 1 | BIRD (PRD_000454) Chemie (ROC) | |||
| 3 | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q72874)
| PDB | External Database | Details |
|---|---|---|
| Val 48 | Gly 536 | engineered mutation |
| Met 90 | Leu 578 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10849.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 670.8 | |
| All* | Total formula weight | 11520.7 |
