Mine: Updated entries

6QPI
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CRYO-EM STRUCTURE OF CALCIUM-FREE MTMEM16F LIPID SCRAMBLASE IN NANODISC
Descriptor:Anoctamin-6
Authors:Alvadia, C., Lim, N.K., Clerico Mosina, V., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-14
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.
Elife, 8, 2019
6QPB
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CRYO-EM STRUCTURE OF CALCIUM-FREE MTMEM16F LIPID SCRAMBLASE IN DIGITONIN
Descriptor:Anoctamin-6, 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Alvadia, C., Lim, N.K., Clerico Mosina, V., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-13
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.
Elife, 8, 2019
6QP0
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CRYSTAL STRUCTURE OF CHAETOMIUM THERMOPHILUM KTI12 IN COMPLEX WITH ADP-ALF3
Descriptor:Putative chromatin binding protein, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ...
Authors:Krutyholowa, R., Glatt, S.
Deposit date:2019-02-13
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator
To Be Published
6QMB
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CRYO-EM STRUCTURE OF CALCIUM-BOUND NHTMEM16 LIPID SCRAMBLASE IN NANODISC (CLOSED STATE)
Descriptor:Predicted protein, CALCIUM ION
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QMA
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CRYO-EM STRUCTURE OF CALCIUM-BOUND NHTMEM16 LIPID SCRAMBLASE IN NANODISC (INTERMEDIATE STATE)
Descriptor:Predicted protein, CALCIUM ION
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QM9
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CRYO-EM STRUCTURE OF CALCIUM-BOUND NHTMEM16 LIPID SCRAMBLASE IN NANODISC (OPEN STATE)
Descriptor:Predicted protein, CALCIUM ION
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QAV
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH MRT68921
Descriptor:Serine/threonine-protein kinase ULK2, ~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAU
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH MRT67307
Descriptor:Serine/threonine-protein kinase ULK2, N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAT
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH HESPERADIN
Descriptor:Serine/threonine-protein kinase ULK2, N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAS
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CRYSTAL STRUCTURE OF ULK1 IN COMPLEXED WITH PF-03814735
Descriptor:Serine/threonine-protein kinase ULK1, SULFATE ION, CITRIC ACID, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QA2
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R80A MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Nucleoside diphosphate kinase, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Dautant, A., Henri, J., Wales, T.E., Meyer, P., Engen, J.R., Georgescauld, F.
Deposit date:2018-12-18
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange.
Biochemistry, 58, 2019
6Q4V
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KLENTAQ DNA POLYMERASE IN COMPLEX WITH DATP
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*(DOC))-3'), ...
Authors:Kropp, H.M., Diederichs, K., Marx, A.
Deposit date:2018-12-06
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.006 Å)
Cite:The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 2019
6Q4U
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KLENTAQ DNA POL IN A CLOSED TERNARY COMPLEX WITH 7-DEAZA-7-(2-(2-HYDROXYETHOXY)-N-(PROP-2-YN-1-YL)ACETAMIDE)-2-DATP
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*(DOC))-3'), ...
Authors:Kropp, H.M., Diederichs, K., Marx, A.
Deposit date:2018-12-06
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 2019
6Q4T
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KOD DNA POL IN A CLOSED TERNARY COMPLEX WITH 7-DEAZA-7-(2-(2-HYDROXYETHOXY)-N-(PROP-2-YN-1-YL)ACETAMIDE)-2-DATP
Descriptor:DNA polymerase,DNA polymerase,DNA polymerase, DNA (5'-D(P*AP*AP*CP*TP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), ...
Authors:Kropp, H.M., Diederichs, K., Marx, A.
Deposit date:2018-12-06
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 2019
6NXE
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CRYO-EM RECONSTRUCTION OF PROTEASE-ACTIVATEABLE ADENO-ASSOCIATED VIRUS 9 (AAV9-L001)
Descriptor:Capsid protein VP1
Authors:Bennett, A.B., Agbandje-Mckenna, M.
Deposit date:2019-02-08
Release date:2019-03-13
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue.
Mol. Ther., 27, 2019
6NT9
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CRYO-EM STRUCTURE OF THE COMPLEX BETWEEN HUMAN TBK1 AND CHICKEN STING
Descriptor:Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of STING binding with and phosphorylation by TBK1.
Nature, 2019
6NT8
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CRYO-EM STRUCTURE OF FULL-LENGTH CHICKEN STING IN THE CGAMP-BOUND TETRAMERIC STATE
Descriptor:Stimulator of interferon genes protein, cGAMP
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 2019
6NT7
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CRYO-EM STRUCTURE OF FULL-LENGTH CHICKEN STING IN THE CGAMP-BOUND DIMERIC STATE
Descriptor:Stimulator of interferon genes protein, cGAMP
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 2019
6NT6
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CRYO-EM STRUCTURE OF FULL-LENGTH CHICKEN STING IN THE APO STATE
Descriptor:Stimulator of interferon genes protein
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 2019
6NT5
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CRYO-EM STRUCTURE OF FULL-LENGTH HUMAN STING IN THE APO STATE
Descriptor:Stimulator of interferon protein
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 2019
6NQA
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ACTIVE STATE DOT1L BOUND TO THE H2B-UBIQUITINATED NUCLEOSOME, 1-TO-1 COMPLEX
Descriptor:601 DNA Strand 1, 601 DNA Strand 2, Histone H4, ...
Authors:Worden, E.J., Hoffmann, N.A., Wolberger, C.
Deposit date:2019-01-19
Release date:2019-02-20
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Cell, 176, 2019
6NOG
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POISED-STATE DOT1L BOUND TO THE H2B-UBIQUITINATED NUCLEOSOME
Descriptor:Histone H3.2, Histone H4, Histone H2A type 1, ...
Authors:Worden, E.J., Hoffmann, N.A., Wolberger, C.
Deposit date:2019-01-16
Release date:2019-02-20
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Cell, 176, 2019
6NNA
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HUMAN FATTY ACID SYNTHASE PSI/KR TRI-DOMAIN WITH NADPH AND COMPOUND 22
Descriptor:Fatty acid synthase,Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {4-[4-(1,3-benzoxazol-2-yl)benzene-1-carbonyl]piperazin-1-yl}(1-hydroxycyclopropyl)methanone, ...
Authors:Toms, A.V., Martin, M.W.
Deposit date:2019-01-14
Release date:2019-02-20
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN).
Bioorg. Med. Chem. Lett., 29, 2019
6NMP
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SFX STRUCTURE OF OXIDIZED CYTOCHROME C OXIDASE AT ROOM TEMPERATURE
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase subunit 3, ...
Authors:Rousseau, D.L., Yeh, S.-R., Ishigami, I.
Deposit date:2019-01-11
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Snapshot of an oxygen intermediate in the catalytic reaction of cytochromecoxidase.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NMF
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SFX STRUCTURE OF REDUCED CYTOCHROME C OXIDASE AT ROOM TEMPERATURE
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase subunit 3, ...
Authors:Rousseau, D.L., Yeh, S.-R., Ishigami, I.
Deposit date:2019-01-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Snapshot of an oxygen intermediate in the catalytic reaction of cytochromecoxidase.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019