2JLB
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XANTHOMONAS CAMPESTRIS PUTATIVE OGT (XCC0866), COMPLEX WITH UDP- GLCNAC PHOSPHONATE ANALOGUE
Descriptor:XCC0866, URIDINE-DIPHOSPHATE-METHYLENE-N-ACETYL-GLUCOSAMINE, MANGANESE (II) ION, ...
Authors:Schuettelkopf, A.W., Clarke, A.J., van Aalten, D.M.F.
Deposit date:2008-09-07
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights Into Mechanism and Specificity of O-Glcnac Transferase.
Embo J., 27, 2008
2VSN
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STRUCTURE AND TOPOLOGICAL ARRANGEMENT OF AN O-GLCNAC TRANSFERASE HOMOLOG: INSIGHT INTO MOLECULAR CONTROL OF INTRACELLULAR GLYCOSYLATION
Descriptor:XCOGT, URIDINE-5'-DIPHOSPHATE
Authors:Martinez-Fleites, C., Macauley, M.S., He, Y., Shen, D., Vocadlo, D., Davies, G.J.
Deposit date:2008-04-28
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of an O-Glcnac Transferase Homolog Provides Insight Into Intracellular Glycosylation.
Nat.Struct.Mol.Biol., 15, 2008
2VSY
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XANTHOMONAS CAMPESTRIS PUTATIVE OGT (XCC0866), APOSTRUCTURE
Descriptor:XCC0866, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Schuettelkopf, A.W., Clarke, A.J., van Aalten, D.M.F.
Deposit date:2008-05-01
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights Into Mechanism and Specificity of O-Glcnac Transferase.
Embo J., 27, 2008
2XGM
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SUBSTRATE AND PRODUCT ANALOGUES AS HUMAN O-GLCNAC TRANSFERASE INHIBITORS.
Descriptor:XCOGT, ALLOXAN
Authors:Dorfmueller, H.C., Borodkin, V.S., Blair, D.E., Pathak, S., Navratilova, I., van Aalten, D.M.
Deposit date:2010-06-07
Release date:2010-08-25
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.
Amino Acids, 40, 2011
2XGO
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XCOGT IN COMPLEX WITH UDP-S-GLCNAC
Descriptor:XCOGT, URIDINE-DIPHOSPHATE-1-DEOXY-1-THIO-N-ACETYLGLUCOSAMINE
Authors:Dorfmueller, H.C., Borodkin, V.S., Blair, D.E., Pathak, S., Navratilova, I., van Aalten, D.M.
Deposit date:2010-06-07
Release date:2010-08-25
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.
Amino Acids, 40, 2011
2XGS
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XCOGT IN COMPLEX WITH C-UDP
Descriptor:XCOGT, 5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE
Authors:Dorfmueller, H.C., Borodkin, V.S., Blair, D.E., Pathak, S., Navratilova, I., van Aalten, D.M.
Deposit date:2010-06-07
Release date:2010-08-25
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.
Amino Acids, 40, 2011
3PE3
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STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE AND ITS COMPLEX WITH A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Nam, Y., Jiang, J., Sliz, P., Walker, S.
Deposit date:2010-10-25
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
Nature, 469, 2011
3PE4
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STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE AND ITS COMPLEX WITH A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Nam, Y., Jiang, J., Sliz, P., Walker, S.
Deposit date:2010-10-25
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
Nature, 469, 2011
3TAX
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A NEUTRAL DIPHOSPHATE MIMIC CROSSLINKS THE ACTIVE SITE OF HUMAN O-GLCNAC TRANSFERASE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Pasquina, L., Sliz, P., Walker, S.
Deposit date:2011-08-04
Release date:2011-11-16
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2011
4AY5
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HUMAN O-GLCNAC TRANSFERASE (OGT) IN COMPLEX WITH UDP AND GLYCOPEPTIDE
Descriptor:UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYL TRANSFERASE 110 KDA SUBUNIT, GTAB1TIDE, URIDINE-5'-DIPHOSPHATE, ...
Authors:Schimpl, M., Zheng, X., Blair, D.E., Schuettelkopf, A.W., Navratilova, I., Aristotelous, T., Ferenbach, A.T., Macnaughtan, M.A., Borodkin, V.S., van Aalten, D.M.F.
Deposit date:2012-06-18
Release date:2012-10-24
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:O-Glcnac Transferase Invokes Nucleotide Sugar Pyrophosphate Participation in Catalysis
Nat.Chem.Biol., 8, 2012
4AY6
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HUMAN O-GLCNAC TRANSFERASE (OGT) IN COMPLEX WITH UDP-5SGLCNAC AND SUBSTRATE PEPTIDE
Descriptor:UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANS FERASE 110 KDA SUBUNIT, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1, SULFATE ION, ...
Authors:Schimpl, M., Zheng, X., Blair, D.E., Schuettelkopf, A.W., Navratilova, I., Aristotelous, T., Ferenbach, A.T., Macnaughtan, M.A., Borodkin, V.S., van Aalten, D.M.F.
Deposit date:2012-06-18
Release date:2012-10-24
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:O-Glcnac Transferase Invokes Nucleotide Sugar Pyrophosphate Participation in Catalysis
Nat.Chem.Biol., 8, 2012
4CDR
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HUMAN O-GLCNAC TRANSFERASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR, GOBLIN1
Descriptor:UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT, GOBLIN1, SULFATE ION, ...
Authors:Schimpl, M., Gundogdu, M., van Aalten, D.M.F.
Deposit date:2013-11-05
Release date:2013-12-04
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Bisubstrate Udp-Peptide Conjugates as Human O-Glcnac Transferase Inhibitors.
Biochem.J., 457, 2014
4GYW
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE IN COMPLEX WITH UDP AND A GLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GYY
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC AND A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ3
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP AND A THIOGLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ5
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.075 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ6
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4N39
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT 2 (11-26)
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3A
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT 2 (1-26)E10A
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3B
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT2(1-26)E10Q AND UDP-5SGLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3C
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT2(1-26) AND UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4XI9
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HUMAN OGT IN COMPLEX WITH UDP-5S-GLCNAC AND SUBSTRATE PEPTIDE (RBL2)
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Retinoblastoma-like protein 2, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Schimpl, M., van Aalten, D.M.F.
Deposit date:2015-01-06
Release date:2015-08-05
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
Nat.Struct.Mol.Biol., 22, 2015
4XIF
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HUMAN OGT IN COMPLEX WITH UDP-5S-GLCNAC AND SUBSTRATE PEPTIDE (KERATIN-7)
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Keratin, type II cytoskeletal 7, ...
Authors:Schimpl, M., van Aalten, D.M.F.
Deposit date:2015-01-06
Release date:2015-08-05
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
Nat.Struct.Mol.Biol., 22, 2015
5A01
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O-GLCNAC TRANSFERASE FROM DROSOSPHILA MELANOGASTER
Descriptor:O-GLYCOSYLTRANSFERASE, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Mariappa, D., Zheng, X., Schimpl, M., Raimi, O., Rafie, K., Ferenbach, A.T., Mueller, H.J., van Aalten, D.M.F.
Deposit date:2015-04-15
Release date:2016-04-27
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Dual functionality of O-GlcNAc transferase is required for Drosophila development.
Open Biol, 5, 2015
5BNW
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THE ACTIVE SITE OF O-GLCNAC TRANSFERASE IMPOSES CONSTRAINTS ON SUBSTRATE SEQUENCE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, laminB1 residues 179-191, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Pathak, S., Alonso, J., Schimpl, M., Rafie, K., Blair, D.E., Borodkin, V.S., Albarbarawi, O., van Aalten, D.M.F.
Deposit date:2015-05-26
Release date:2015-08-05
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
Nat.Struct.Mol.Biol., 22, 2015
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