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5ZSU
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BU of 5zsu by Molmil
Structure of the human homo-hexameric LRRC8A channel at 4.25 Angstroms
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Kasuya, G, Nakane, T, Yokoyama, T, Shirouzu, M, Ishitani, R, Nureki, O.
Deposit date:2018-04-29
Release date:2018-08-15
Last modified:2018-09-26
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Cryo-EM structures of the human volume-regulated anion channel LRRC8.
Nat. Struct. Mol. Biol., 25, 2018
7XZH
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BU of 7xzh by Molmil
Cryo-EM structure of human LRRC8A
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ...
Authors:Liu, H, Liao, J.
Deposit date:2022-06-02
Release date:2023-06-07
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:cryo-EM structure of human LRRC8A
To Be Published
6G8Z
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BU of 6g8z by Molmil
Structure of the pore domain of homomeric mLRRC8A volume-regulated anion channel at 3.66 A resolution
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R.
Deposit date:2018-04-10
Release date:2018-05-16
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structure of a volume-regulated anion channel of the LRRC8 family.
Nature, 558, 2018
6G9L
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BU of 6g9l by Molmil
Structure of homomeric mLRRC8A volume-regulated anion channel at 5.01 A resolution
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R.
Deposit date:2018-04-11
Release date:2018-05-16
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.01 Å)
Cite:Structure of a volume-regulated anion channel of the LRRC8 family.
Nature, 558, 2018
7M19
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BU of 7m19 by Molmil
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Gerber, E.E, Brohawn, S.G.
Deposit date:2021-03-12
Release date:2021-03-24
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022
7M17
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BU of 7m17 by Molmil
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Gerber, E.E, Brohawn, S.G.
Deposit date:2021-03-12
Release date:2021-03-24
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022
6DJB
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BU of 6djb by Molmil
Structure of human Volume Regulated Anion Channel composed of SWELL1 (LRRC8A)
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Kefauver, J.M, Saotome, K, Pallesen, J, Cottrell, C.A, Ward, A.B, Patapoutian, A.
Deposit date:2018-05-24
Release date:2018-08-15
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of the human volume regulated anion channel.
Elife, 7, 2018
6G9O
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BU of 6g9o by Molmil
Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R.
Deposit date:2018-04-11
Release date:2018-05-16
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Structure of a volume-regulated anion channel of the LRRC8 family.
Nature, 558, 2018
8B40
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BU of 8b40 by Molmil
Structure of homomeric LRRC8C Volume-Regulated Anion Channel
Descriptor: Volume-regulated anion channel subunit LRRC8C
Authors:Sawicka, M, Dutzler, R.
Deposit date:2022-09-19
Release date:2022-12-14
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8B41
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BU of 8b41 by Molmil
Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1
Descriptor: Synthetic nanobody Sb1, Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C
Authors:Sawicka, M, Dutzler, R.
Deposit date:2022-09-19
Release date:2022-12-14
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8B42
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BU of 8b42 by Molmil
Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel.
Descriptor: Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C
Authors:Sawicka, M, Dutzler, R.
Deposit date:2022-09-19
Release date:2022-12-14
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
6M04
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BU of 6m04 by Molmil
Structure of the human homo-hexameric LRRC8D channel at 4.36 Angstroms
Descriptor: Volume-regulated anion channel subunit LRRC8D
Authors:Nakamura, R, Kasuya, G, Yokoyama, T, Shirouzu, M, Ishitani, R, Nureki, O.
Deposit date:2020-02-20
Release date:2020-06-17
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Commun Biol, 3, 2020
6NZZ
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BU of 6nzz by Molmil
LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6O00
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BU of 6o00 by Molmil
apo-LRRC8A in MSP2N2 nanodisc constricted state
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6NZW
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BU of 6nzw by Molmil
LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
7P60
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BU of 7p60 by Molmil
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4 at 1:0.5 ratio
Descriptor: Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb4
Authors:Deneka, D, Rutz, S, Sawicka, M.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
Nat Commun, 12, 2021
7P5V
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BU of 7p5v by Molmil
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1
Descriptor: Synthetic nanobody Sb1, Volume-regulated anion channel subunit LRRC8A
Authors:Deneka, D, Rutz, S, Sawicka, M.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
Nat Commun, 12, 2021
7P5Y
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BU of 7p5y by Molmil
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3
Descriptor: Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb3
Authors:Deneka, D, Rutz, S, Sawicka, M.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
Nat Commun, 12, 2021
7P5W
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BU of 7p5w by Molmil
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2
Descriptor: Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb2
Authors:Deneka, D, Rutz, S, Sawicka, M.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
Nat Commun, 12, 2021
7P6K
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BU of 7p6k by Molmil
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb5
Descriptor: Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb5
Authors:Deneka, D, Rutz, S, Sawicka, M.
Deposit date:2021-07-16
Release date:2021-09-15
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
Nat Commun, 12, 2021
8DXR
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BU of 8dxr by Molmil
Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 5
Descriptor: Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A
Authors:Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E.
Deposit date:2022-08-02
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly.
Elife, 12, 2023
8DXN
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BU of 8dxn by Molmil
Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 1
Descriptor: Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A
Authors:Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E.
Deposit date:2022-08-02
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly.
Elife, 12, 2023
8DXO
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BU of 8dxo by Molmil
Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 2
Descriptor: Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A
Authors:Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E.
Deposit date:2022-08-02
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly.
Elife, 12, 2023
8DXP
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BU of 8dxp by Molmil
Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 3
Descriptor: Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A
Authors:Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E.
Deposit date:2022-08-02
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly.
Elife, 12, 2023
8DXQ
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BU of 8dxq by Molmil
Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 4
Descriptor: Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A
Authors:Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E.
Deposit date:2022-08-02
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly.
Elife, 12, 2023

 

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