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6D6J
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BU of 6d6j by Molmil
Crystal structure of HIT family hydrolase from Legionella pneumophila Philadelphia 1
Descriptor: CHLORIDE ION, HIT family hydrolase, ZINC ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-04-21
Release date:2018-05-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structure of HIT family hydrolase from Legionella pneumophila Philadelphia 1
to be published
6CVQ
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BU of 6cvq by Molmil
Human Aprataxin (Aptx) H201Q bound to RNA-DNA, AMP and Zn product complex
Descriptor: ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
3BL9
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BU of 3bl9 by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG157493
Descriptor: 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
1VLR
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BU of 1vlr by Molmil
Crystal structure of mRNA decapping enzyme (DcpS) from Mus musculus at 1.83 A resolution
Descriptor: 1,2-ETHANEDIOL, mRNA decapping enzyme
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2004-08-10
Release date:2004-08-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution.
Proteins, 60, 2005
4NDH
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BU of 4ndh by Molmil
Human Aprataxin (Aptx) bound to DNA, AMP, and Zn - product complex
Descriptor: 5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3', ADENOSINE MONOPHOSPHATE, Aprataxin, ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
6CVR
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BU of 6cvr by Molmil
Human Aprataxin (Aptx) S242N bound to RNA-DNA, AMP and Zn product complex
Descriptor: ADENOSINE MONOPHOSPHATE, Aprataxin, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
1ST0
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BU of 1st0 by Molmil
Structure of DcpS bound to m7GpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, YTTRIUM (III) ION, mRNA decapping enzyme
Authors:Gu, M, Fabrega, C, Liu, S.W, Liu, H, Kiledjian, M, Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004
4NDI
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BU of 4ndi by Molmil
Human Aprataxin (Aptx) AOA1 variant K197Q bound to RNA-DNA, AMP, and Zn - product complex
Descriptor: 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', ADENOSINE MONOPHOSPHATE, ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
4NDF
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BU of 4ndf by Molmil
Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex
Descriptor: 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', ADENOSINE MONOPHOSPHATE, ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.944 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
6GBS
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BU of 6gbs by Molmil
Crystal Structure of the C. themophilum Scavenger Decapping Enzyme DcpS apo form
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Putative mRNA decapping protein
Authors:Fuchs, A.-L, Neu, A, Sprangers, R.
Deposit date:2018-04-16
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.946 Å)
Cite:Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme.
Proc.Natl.Acad.Sci.USA, 117, 2020
6CVP
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BU of 6cvp by Molmil
Human Aprataxin (Aptx) R199H bound to RNA-DNA, AMP and Zn product complex
Descriptor: ADENOSINE MONOPHOSPHATE, Aprataxin, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ...
Authors:Schellenberg, M.J, Williams, R.S, Tumbale, P.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
1XML
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BU of 1xml by Molmil
Structure of human Dcps
Descriptor: PHOSPHATE ION, heat shock-like protein 1
Authors:Chen, N, Song, H.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
J.Mol.Biol., 347, 2005
1ST4
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BU of 1st4 by Molmil
Structure of DcpS bound to m7GpppA
Descriptor: P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, YTTRIUM (III) ION, mRNA decapping enzyme
Authors:Gu, M, Fabrega, C, Liu, S.W, Liu, H, Kiledjian, M, Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004
5OSY
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BU of 5osy by Molmil
Human Decapping Scavenger enzyme (hDcpS) in complex with m7G(5'S)ppSp(5'S)G mRNA 5' cap analog
Descriptor: GLYCEROL, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl]oxy-phosphinic acid, m7GpppX diphosphatase
Authors:Warminski, M, Nowak, E, Wojtczak, B.A, Fac-Dabrowska, K, Kubacka, D, Nowicka, A, Sikorski, P.J, Kowalska, J, Jemielity, J, Nowotny, M.
Deposit date:2017-08-18
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.
J. Am. Chem. Soc., 140, 2018
6CVS
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BU of 6cvs by Molmil
Human Aprataxin (Aptx) L248M bound to DNA, AMP and Zn product
Descriptor: ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
5BV3
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BU of 5bv3 by Molmil
Yeast Scavenger Decapping Enzyme in complex with m7GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, CHLORIDE ION, SULFATE ION, ...
Authors:Neu, A, Neu, U, Sprangers, R.
Deposit date:2015-06-04
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:An excess of catalytically required motions inhibits the scavenger decapping enzyme.
Nat.Chem.Biol., 11, 2015
5UVM
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BU of 5uvm by Molmil
HIT family hydrolase from Clostridium thermocellum Cth-393
Descriptor: ADENOSINE, Histidine triad (HIT) protein, UNKNOWN ATOM OR ION, ...
Authors:Habel, J, Tempel, W, Liu, Z.-J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2017-02-20
Release date:2017-04-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:HIT family hydrolase from Clostridium thermocellum Cth-393
To Be Published
3BL7
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BU of 3bl7 by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG156844
Descriptor: 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
6CVO
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BU of 6cvo by Molmil
Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex
Descriptor: ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ...
Authors:Schellenberg, M.J, Tumbale, P.P, Williams, R.S.
Deposit date:2018-03-28
Release date:2018-08-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
1XMM
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BU of 1xmm by Molmil
Structure of human Dcps bound to m7GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, N7-METHYL-GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:Chen, N, Song, H.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
J.Mol.Biol., 347, 2005
4NDG
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BU of 4ndg by Molmil
Human Aprataxin (Aptx) bound to RNA-DNA and Zn - adenosine vanadate transition state mimic complex
Descriptor: 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', Aprataxin, ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
3BLA
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BU of 3bla by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG153249
Descriptor: 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
4QDV
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BU of 4qdv by Molmil
Dcps in complex with covalent ligand
Descriptor: 4-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid, GLYCEROL, PHOSPHATE ION, ...
Authors:Liu, S.
Deposit date:2014-05-14
Release date:2015-05-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dcps in complex with covalent ligands targeting Tyrosines
To be Published
4QDE
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BU of 4qde by Molmil
Dcps in complex with covalent inhibitor
Descriptor: 2-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid, PHOSPHATE ION, m7GpppX diphosphatase
Authors:Liu, S.
Deposit date:2014-05-13
Release date:2015-05-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Dcps in complex with covalent inhibitors
To be Published
6CVT
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BU of 6cvt by Molmil
Human Aprataxin (Aptx) V263G bound to RNA-DNA, AMP and Zn product complex
Descriptor: ADENOSINE MONOPHOSPHATE, Aprataxin, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ...
Authors:Schellenberg, M.J, Tumbale, P.S, Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.941 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018

 

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