5UVM
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HIT FAMILY HYDROLASE FROM CLOSTRIDIUM THERMOCELLUM CTH-393
Descriptor:Histidine triad (HIT) protein, ZINC ION, UNKNOWN ATOM OR ION, ...
Authors:Habel, J., Tempel, W., Liu, Z.-J., Rose, J., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2017-02-20
Release date:2017-04-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:HIT family hydrolase from Clostridium thermocellum Cth-393
To Be Published
6CVQ
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HUMAN APRATAXIN (APTX) H201Q BOUND TO RNA-DNA, AMP AND ZN PRODUCT COMPLEX
Descriptor:Aprataxin, DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
4NDF
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HUMAN APRATAXIN (APTX) BOUND TO RNA-DNA, AMP, AND ZN - PRODUCT COMPLEX
Descriptor:Aprataxin, 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.944 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
4NDG
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HUMAN APRATAXIN (APTX) BOUND TO RNA-DNA AND ZN - ADENOSINE VANADATE TRANSITION STATE MIMIC COMPLEX
Descriptor:Aprataxin, 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
4NDH
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HUMAN APRATAXIN (APTX) BOUND TO DNA, AMP, AND ZN - PRODUCT COMPLEX
Descriptor:Aprataxin, 5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3', ADENOSINE MONOPHOSPHATE, ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
4NDI
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HUMAN APRATAXIN (APTX) AOA1 VARIANT K197Q BOUND TO RNA-DNA, AMP, AND ZN - PRODUCT COMPLEX
Descriptor:Aprataxin, 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2013-10-26
Release date:2013-12-18
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506, 2013
6CVO
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HUMAN APRATAXIN (APTX) BOUND TO NICKED RNA-DNA, AMP AND ZN PRODUCT COMPLEX
Descriptor:Aprataxin, DNA/RNA (5'-R(P*G)-D(P*TP*TP*CP*TP*AP*TP*AP*TP*AP*TP*AP*GP*AP*AP*CP*GP*CP*TP*GP*TP*T)-3'), DNA (5'-D(*AP*AP*CP*AP*GP*C)-3'), ...
Authors:Schellenberg, M.J., Tumbale, P.P., Williams, R.S.
Deposit date:2018-03-28
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
6CVP
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HUMAN APRATAXIN (APTX) R199H BOUND TO RNA-DNA, AMP AND ZN PRODUCT COMPLEX
Descriptor:Aprataxin, DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ...
Authors:Schellenberg, M.J., Williams, R.S., Tumbale, P.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
6CVR
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HUMAN APRATAXIN (APTX) S242N BOUND TO RNA-DNA, AMP AND ZN PRODUCT COMPLEX
Descriptor:Aprataxin, DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
6CVS
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HUMAN APRATAXIN (APTX) L248M BOUND TO DNA, AMP AND ZN PRODUCT
Descriptor:Aprataxin, DNA (5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3'), ADENOSINE MONOPHOSPHATE, ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
6CVT
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HUMAN APRATAXIN (APTX) V263G BOUND TO RNA-DNA, AMP AND ZN PRODUCT COMPLEX
Descriptor:Aprataxin, DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ...
Authors:Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
Deposit date:2018-03-28
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.941 Å)
Cite:Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
1ST0
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STRUCTURE OF DCPS BOUND TO M7GPPPG
Descriptor:mRNA decapping enzyme, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, YTTRIUM (III) ION
Authors:Gu, M., Fabrega, C., Liu, S.W., Liu, H., Kiledjian, M., Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004
1ST4
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STRUCTURE OF DCPS BOUND TO M7GPPPA
Descriptor:mRNA decapping enzyme, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, YTTRIUM (III) ION
Authors:Gu, M., Fabrega, C., Liu, S.W., Liu, H., Kiledjian, M., Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004
1VLR
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CRYSTAL STRUCTURE OF MRNA DECAPPING ENZYME (DCPS) FROM MUS MUSCULUS AT 1.83 A RESOLUTION
Descriptor:mRNA decapping enzyme, 1,2-ETHANEDIOL
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2004-08-10
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution.
Proteins, 60, 2005
1XML
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STRUCTURE OF HUMAN DCPS
Descriptor:heat shock-like protein 1, PHOSPHATE ION
Authors:Chen, N., Song, H.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
J.Mol.Biol., 347, 2005
1XMM
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STRUCTURE OF HUMAN DCPS BOUND TO M7GDP
Descriptor:heat shock-like protein 1, PHOSPHATE ION, N7-METHYL-GUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Chen, N., Song, H.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
J.Mol.Biol., 347, 2005
3BL7
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG156844
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL9
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG157493
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BLA
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG153249
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
4QDE
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DCPS IN COMPLEX WITH COVALENT INHIBITOR
Descriptor:m7GpppX diphosphatase, PHOSPHATE ION, 2-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid
Authors:Liu, S.
Deposit date:2014-05-13
Release date:2015-05-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Dcps in complex with covalent inhibitors
To be Published
4QDV
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DCPS IN COMPLEX WITH COVALENT LIGAND
Descriptor:m7GpppX diphosphatase, 4-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid, PHOSPHATE ION, ...
Authors:Liu, S.
Deposit date:2014-05-14
Release date:2015-05-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dcps in complex with covalent ligands targeting Tyrosines
To be Published
4QEB
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DCPS IN COMPLEX WITH COVALENT INHIBITOR TARGETING TYROSINE
Descriptor:m7GpppX diphosphatase, PHOSPHATE ION, 3-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid
Authors:Liu, S.
Deposit date:2014-05-15
Release date:2015-05-20
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Human Dcps in complex with covalent inhibitor
To be Published
5BV3
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YEAST SCAVENGER DECAPPING ENZYME IN COMPLEX WITH M7GDP
Descriptor:m7GpppX diphosphatase, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Neu, A., Neu, U., Sprangers, R.
Deposit date:2015-06-04
Release date:2015-08-12
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:An excess of catalytically required motions inhibits the scavenger decapping enzyme.
Nat.Chem.Biol., 11, 2015
5OSY
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HUMAN DECAPPING SCAVENGER ENZYME (HDCPS) IN COMPLEX WITH M7G(5'S)PPSP(5'S)G MRNA 5' CAP ANALOG
Descriptor:m7GpppX diphosphatase, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl]oxy-phosphinic acid, GLYCEROL
Authors:Warminski, M., Nowak, E., Wojtczak, B.A., Fac-Dabrowska, K., Kubacka, D., Nowicka, A., Sikorski, P.J., Kowalska, J., Jemielity, J., Nowotny, M.
Deposit date:2017-08-18
Release date:2018-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.
J. Am. Chem. Soc., 140, 2018
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