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1B12	CRYSTAL STRUCTURE OF TYPE 1 SIGNAL PEPTIDASE FROM ESCHERICHIA COLI IN COMPLEX WITH A BETA-LACTAM INHIBITOR Descriptor: PHOSPHATE ION, SIGNAL PEPTIDASE I, prop-2-en-1-yl (2S)-2-[(2S,3R)-3-(acetyloxy)-1-oxobutan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylate Authors: Paetzel, M, Dalbey, R, Strynadka, N.C.J. Deposit date: 1999-11-24 Release date: 1999-12-10 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor. Nature, 396, 1998
1KN9	CRYSTAL STRUCTURE OF A BACTERIAL SIGNAL PEPTIDASE APO-ENZYME, IMPLICATIONS FOR SIGNAL PEPTIDE BINDING AND THE SER-LYS DYAD MECHANISM. Descriptor: Signal peptidase I Authors: Paetzel, M, Dalbey, R.E, Strynadka, N.C.J. Deposit date: 2001-12-18 Release date: 2002-01-30 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism J.Biol.Chem., 277, 2002
1T7D	Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor Descriptor: 10-METHYLUNDECANOIC ACID, ARYLOMYCIN A2, SIGNAL PEPTIDASE I Authors: Paetzel, M, Goodall, J.J, Kania, M, Dalbey, R.E, Page, M.G.P. Deposit date: 2004-05-09 Release date: 2004-07-13 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor. J.Biol.Chem., 279, 2004
3IIQ	Crystallographic analysis of bacterial signal peptidase in ternary complex with Arylomycin A2 and a beta-sultam inhibitor Descriptor: 10-METHYLUNDECANOIC ACID, 4-[(1,1-dioxido-1,2-thiazetidin-2-yl)carbonyl]morpholine, ACETONITRILE, ... Authors: Paetzel, M. Deposit date: 2009-08-03 Release date: 2009-09-01 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a Beta-Sultam Inhibitor. Biochemistry, 48, 2009
3S04	Crystal structure of Escherichia coli type I signal peptidase in complex with an Arylomycin Lipoglycopeptide Antibiotic Descriptor: 14-methylhexadec-9-enoic acid, Glyco-Arylomycin, Signal peptidase I, ... Authors: Paetzel, M, Luo, C. Deposit date: 2011-05-13 Release date: 2011-10-05 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase. J.Am.Chem.Soc., 133, 2011
4K8W	An arm-swapped dimer of the S. pyogenes pilin specific assembly factor SipA Descriptor: 1,2-ETHANEDIOL, ETHANOL, LepA Authors: Young, P.G, Kang, H.J, Baker, E.N. Deposit date: 2013-04-19 Release date: 2013-06-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.67 Å) Cite: An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA. J.Struct.Biol., 183, 2013
4ME8	Crystal structure of a signal peptidase I (EF3073) from Enterococcus faecalis V583 at 2.27 A resolution Descriptor: 1,2-ETHANEDIOL, Signal peptidase I Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2013-08-25 Release date: 2013-09-11 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Crystal structure of a signal peptidase I (EF3073) from Enterococcus faecalis V583 at 2.27 A resolution To be published
4NV4	1.8 Angstrom Crystal Structure of Signal Peptidase I from Bacillus anthracis. Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Signal peptidase I, ... Authors: Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Shatsman, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2013-12-04 Release date: 2013-12-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: 1.8 Angstrom Crystal Structure of Signal Peptidase I from Bacillus anthracis. TO BE PUBLISHED
4N31	Structure and activity of Streptococcus pyogenes SipA: a signal peptidase homologue essential for pilus polymerisation Descriptor: PHOSPHATE ION, PHOSPHATIDYLETHANOLAMINE, SipA Authors: Young, P.G, Proft, T, Baker, E.N. Deposit date: 2013-10-06 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure and activity of Streptococcus pyogenes SipA: a signal peptidase-like protein essential for pilus polymerisation. Plos One, 9, 2014
4WVG	Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB). Descriptor: Maltose-binding periplasmic protein,Signal peptidase IB, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Young, P.G, Ting, Y.T, Baker, E.N. Deposit date: 2014-11-05 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization. IUCrJ, 3, 2016
4WVI	Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with a substrate peptide (pep2). Descriptor: Maltose-binding periplasmic protein,Signal peptidase IB, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, substrate peptide (pep2) Authors: Young, P.G, Ting, Y.T, Baker, E.N. Deposit date: 2014-11-05 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization. IUCrJ, 3, 2016
4WVJ	Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with an inhibitor peptide (pep3). Descriptor: Maltose-binding periplasmic protein,Signal peptidase IB, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, inhibitor peptide (PEP3) Authors: Young, P.G, Ting, Y.T, Baker, E.N. Deposit date: 2014-11-05 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization. IUCrJ, 3, 2016
6B88	E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide) Descriptor: (8S,11S,14S)-14-{[(2S)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2Z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19),2(20),3,5,15,17-hexaene-8-carboxamide, PENTAETHYLENE GLYCOL, Signal peptidase I Authors: Murray, J.M, Rouge, L. Deposit date: 2017-10-05 Release date: 2018-10-10 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.407 Å) Cite: Optimized arylomycins are a new class of Gram-negative antibiotics. Nature, 561, 2018