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1HTY
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BU of 1hty by Molmil
GOLGI ALPHA-MANNOSIDASE II
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R.
Deposit date:2001-01-02
Release date:2002-01-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HWW
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BU of 1hww by Molmil
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R.
Deposit date:2001-01-10
Release date:2002-01-10
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HXK
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BU of 1hxk by Molmil
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-DEOXYMANNOJIRIMYCIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R.
Deposit date:2001-01-16
Release date:2002-01-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1O7D
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The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Heikinheimo, P, Helland, R, Leiros, H.S, Leiros, I, Karlsen, S, Evjen, G, Ravelli, R, Schoehn, G, Ruigrok, R, Tollersrud, O.-K, Mcsweeney, S, Hough, E.
Deposit date:2002-10-30
Release date:2003-03-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of Bovine Lysosomal Alpha-Mannosidase Suggests a Novel Mechanism for Low-Ph Activation
J.Mol.Biol., 327, 2003
1PS3
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BU of 1ps3 by Molmil
Golgi alpha-mannosidase II in complex with kifunensine
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase II, ...
Authors:Shah, N, Kuntz, D.A, Rose, D.R.
Deposit date:2003-06-20
Release date:2003-12-16
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms
Biochemistry, 42, 2003
1QWN
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GOLGI ALPHA-MANNOSIDASE II Covalent Intermediate Complex with 5-fluoro-gulosyl-fluoride
Descriptor: (2R,3S,4R,5S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R.
Deposit date:2003-09-02
Release date:2003-10-07
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1QWU
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Golgi alpha-mannosidase II D341N mutant complex with 5-F-guloside
Descriptor: (2R,3S,4R,5S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R.
Deposit date:2003-09-03
Release date:2003-10-07
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1QX1
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Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-2-fluoro-beta-D-mannopyranosyl fluoride, ...
Authors:Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R.
Deposit date:2003-09-04
Release date:2003-10-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1R33
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Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamine
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-thio-alpha-D-mannopyranosylamine, ...
Authors:Kuntz, D.A, Xin, W, Kavelekar, L.M, Rose, D.R, Pinto, B.M.
Deposit date:2003-09-30
Release date:2004-11-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling
TETRAHEDRON ASYMMETRY, 16, 2005
1R34
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BU of 1r34 by Molmil
Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamidinium salt
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(1Z)-2-phenylethanimidoyl]-5-thio-alpha-D-mannopyranosylamine, ...
Authors:Kuntz, D.A, Xin, W, Kavelekar, L.M, Rose, D.R, Pinto, B.M.
Deposit date:2003-09-30
Release date:2004-11-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling
TETRAHEDRON ASYMMETRY, 16, 2005
1TQV
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Golgi alpha-Mannosidase II In Complex With Seleno-Salacinol (Blintol)
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2S,3S)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISELENONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R.
Deposit date:2004-06-18
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
TETRAHEDRON ASYMMETRY, 16, 2005
1TQT
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Golgi alpha-Mannosidase II In Complex With A Diastereomer of Salacinol
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2R,3R)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISULFONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQW
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BU of 1tqw by Molmil
Golgi alpha-Mannosidase II In Complex With A Diastereomer of Seleno-Salacinol
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2R,3R)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISELENONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R.
Deposit date:2004-06-18
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Insights into the Mechanism of Drosophila melanogaster Golgi a-Mannosidase II Through Crystallographic Analysis of the Interactions with Analogues of the Naturally Occurring Glycomimetic Salacinol
TETRAHEDRON ASYMMETRY, 16, 2005
1TQS
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BU of 1tqs by Molmil
Golgi alpha-Mannosidase II In Complex With Salacinol
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2S,3S)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISULFONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQU
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BU of 1tqu by Molmil
Golgi alpha-Mannosidase II In Complex With The Salacinol Analog Ghavamiol
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1'-((1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL)-4-N-AMMONIUM)-1'-DEOXY-L-ERYTHRITOL-3'-SULFATE INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
2ALW
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BU of 2alw by Molmil
Golgi alpha-mannosidase II complex with Noeuromycin
Descriptor: (2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Bols, M.B, Liu, H, Rose, D.R.
Deposit date:2005-08-08
Release date:2006-07-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The role of the active site Zn in the catalytic mechanism of the GH38 Golgi alpha-mannosidase II: implications from noeuromycin inhibition
Biocatal.Biotransfor., 34, 2006
2F1A
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BU of 2f1a by Molmil
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S)-2-({[(1S)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3,4-diol
Descriptor: (2R,3R,4S)-2-({[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F1B
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BU of 2f1b by Molmil
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S,5R)-2-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)-5-methylpyrrolidine-3,4-diol
Descriptor: (2R,3R,4S,5R)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)-5-METHYLPYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F18
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GOLGI ALPHA-MANNOSIDASE II complex with (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3,4-diol
Descriptor: (2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F7O
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Golgi alpha-mannosidase II complex with mannostatin A
Descriptor: (1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Rose, D.R.
Deposit date:2005-12-01
Release date:2006-07-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions.
J.Am.Chem.Soc., 128, 2006
2F7Q
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BU of 2f7q by Molmil
Golgi alpha-mannosidase II complex with aminocyclopentitetrol
Descriptor: (1R,2R,3S,4S,5R)-5-AMINOCYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Rose, D.R.
Deposit date:2005-12-01
Release date:2006-12-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Golgi alpha-mannosidase II complex with aminocyclopentitetrol
To be Published
2F7P
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BU of 2f7p by Molmil
Golgi alpha-mannosidase II complex with benzyl-mannostatin A
Descriptor: (1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Rose, D.R.
Deposit date:2005-12-01
Release date:2006-07-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions.
J.Am.Chem.Soc., 128, 2006
2F7R
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BU of 2f7r by Molmil
Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol
Descriptor: (1R,2R,3S,4S,5R)-5-(BENZYLAMINO)CYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A, Rose, D.R.
Deposit date:2005-12-01
Release date:2006-12-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol
To be Published
2FYV
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BU of 2fyv by Molmil
Golgi alpha-mannosidase II complex with an amino-salacinol carboxylate analog
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-DEOXY-6-[(2R,3R,4R)-3,4-DIHYDROXY-2-(HYDROXYMETHYL)PYRROLIDIN-1-YL]-L-GULONIC ACID, ...
Authors:Kuntz, D.A, Hamlet, T, Rose, D.R.
Deposit date:2006-02-08
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids.
Bioorg.Med.Chem., 14, 2006
2OW6
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Golgi alpha-mannosidase II complex with (1r,5s,6s,7r,8s)-1-thioniabicyclo[4.3.0]nonan-5,7,8-triol chloride
Descriptor: (1R,5S,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-5,7,8-TRIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kuntz, D.A.
Deposit date:2007-02-15
Release date:2008-01-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: The role of water in inhibitor binding.
Proteins, 71, 2008

 

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