Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
4DV8
DownloadVisualize
BU of 4dv8 by Molmil
Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
Descriptor: (2S)-6-[(4-fluorobenzyl)amino]-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide, Lethal factor, MALONATE ION, ...
Authors:Margosiak, S.A, Sankaran, B.
Deposit date:2012-02-22
Release date:2012-03-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.632 Å)
Cite:Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorg.Med.Chem.Lett., 22, 2012
4PKW
DownloadVisualize
BU of 4pkw by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor GM6001
Descriptor: 1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ...
Authors:Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
5D1S
DownloadVisualize
BU of 5d1s by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
Descriptor: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide, ZINC ION
Authors:Maize, K.M, Finzel, B.C.
Deposit date:2015-08-04
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
4PKR
DownloadVisualize
BU of 4pkr by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 10
Descriptor: CHLORIDE ION, GLYCEROL, Lethal factor, ...
Authors:Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKQ
DownloadVisualize
BU of 4pkq by Molmil
Anthrax toxin lethal factor with bound zinc
Descriptor: 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ...
Authors:Maize, K.M, Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
5D1T
DownloadVisualize
BU of 5d1t by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
Descriptor: Lethal factor, N~2~-[3-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:Maize, K.M, Finzel, B.C.
Deposit date:2015-08-04
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
1J7N
DownloadVisualize
BU of 1j7n by Molmil
Anthrax Toxin Lethal factor
Descriptor: Lethal Factor precursor, SULFATE ION, ZINC ION
Authors:Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
Deposit date:2001-05-17
Release date:2001-11-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
4PKS
DownloadVisualize
BU of 4pks by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 11
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ...
Authors:Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
1YQY
DownloadVisualize
BU of 1yqy by Molmil
Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor
Descriptor: (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, Lethal factor, ZINC ION
Authors:Shoop, W.L, Xiong, Y, Wiltsie, J, Woods, A, Guo, J, Pivnichny, J.V, Felcetto, T, Michael, B.F, Bansal, A.
Deposit date:2005-02-02
Release date:2005-05-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Anthrax lethal factor inhibition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
4XM6
DownloadVisualize
BU of 4xm6 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
Descriptor: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
Authors:Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
Deposit date:2015-01-14
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4PKU
DownloadVisualize
BU of 4pku by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 15
Descriptor: Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKT
DownloadVisualize
BU of 4pkt by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 13
Descriptor: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION
Authors:Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKV
DownloadVisualize
BU of 4pkv by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 16
Descriptor: Lethal factor, N~2~-[4-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:Maize, K.M, Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4WF6
DownloadVisualize
BU of 4wf6 by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor MK-31
Descriptor: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ...
Authors:Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
Deposit date:2014-09-12
Release date:2015-09-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6521 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
1ZXV
DownloadVisualize
BU of 1zxv by Molmil
X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.
Descriptor: (E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID, ZINC ION, lethal factor
Authors:Wong, T.Y, Liddington, R.C.
Deposit date:2005-06-08
Release date:2005-07-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Efficient synthetic inhibitors of anthrax lethal factor.
Proc.Natl.Acad.Sci.Usa, 102, 2005
4XM8
DownloadVisualize
BU of 4xm8 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
Descriptor: Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION
Authors:Maize, K.M, Finzel, B.C.
Deposit date:2015-01-14
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM7
DownloadVisualize
BU of 4xm7 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
Descriptor: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
Authors:Maize, K.M, Finzel, B.C.
Deposit date:2015-01-14
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
1PWU
DownloadVisualize
BU of 1pwu by Molmil
Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.
Descriptor: 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION
Authors:Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-02-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
DownloadVisualize
BU of 1pww by Molmil
Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
Descriptor: LF20, Lethal factor, ZINC ION
Authors:Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
DownloadVisualize
BU of 1pwv by Molmil
Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.
Descriptor: LF20, Lethal factor
Authors:Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-02-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
5D1U
DownloadVisualize
BU of 5d1u by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
Descriptor: Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:Maize, K.M, Finzel, B.C.
Deposit date:2015-08-04
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8503 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
1PWP
DownloadVisualize
BU of 1pwp by Molmil
Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155
Descriptor: Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION
Authors:Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
6ZXJ
DownloadVisualize
BU of 6zxj by Molmil
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state, in which the third lethal factor is masked out (PA7LF3-masked)
Descriptor: Lethal factor, Protective antigen
Authors:Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S.
Deposit date:2020-07-29
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
Plos Pathog., 16, 2020
1PWQ
DownloadVisualize
BU of 1pwq by Molmil
Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor
Descriptor: Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION
Authors:Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
6ZXK
DownloadVisualize
BU of 6zxk by Molmil
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement
Descriptor: Lethal factor, Protective antigen
Authors:Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S.
Deposit date:2020-07-29
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
Plos Pathog., 16, 2020

 

12>

218500

PDB entries from 2024-04-17

PDB statisticsPDBj update infoContact PDBjnumon