1J7N
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ANTHRAX TOXIN LETHAL FACTOR
Descriptor:Lethal Factor precursor, SULFATE ION, ZINC ION
Authors:Pannifer, A.D., Wong, T.Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Collier, R.J., Bienkowska, J., Lacy, D.B., Park, S., Leppla, S.H., Hanna, P., Liddington, R.C.
Deposit date:2001-05-17
Release date:2001-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1JKY
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CRYSTAL STRUCTURE OF THE ANTHRAX LETHAL FACTOR (LF): WILD-TYPE LF COMPLEXED WITH THE N-TERMINAL SEQUENCE OF MAPKK2
Descriptor:Lethal Factor, mitogen-activated protein kinase kinase 2
Authors:Pannifer, A.D., Wong, T.Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Collier, R.J., Bienkowska, J., Lacy, D.B., Park, S., Leppla, S.H., Hanna, P., Liddington, R.C.
Deposit date:2001-07-13
Release date:2001-11-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1PWP
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CRYSTAL STRUCTURE OF THE ANTHRAX LETHAL FACTOR COMPLEXED WITH SMALL MOLECULE INHIBITOR NSC 12155
Descriptor:Lethal factor, ZINC ION, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWQ
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH THIOACETYL-TYR-PRO-MET-AMIDE, A METAL-CHELATING PEPTIDYL SMALL MOLECULE INHIBITOR
Descriptor:Lethal factor, ZINC ION, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWU
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH (3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE), A KNOWN SMALL MOLECULE INHIBITOR OF MATRIX METALLOPROTEASES.
Descriptor:Lethal factor, ZINC ION, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR WILD-TYPE PROTEIN COMPLEXED WITH AN OPTIMISED PEPTIDE SUBSTRATE.
Descriptor:Lethal factor, LF20
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR ACTIVE SITE MUTANT PROTEIN COMPLEXED WITH AN OPTIMISED PEPTIDE SUBSTRATE IN THE PRESENCE OF ZINC.
Descriptor:Lethal factor, LF20, ZINC ION
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1YQY
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STRUCTURE OF B. ANTHRAX LETHAL FACTOR IN COMPLEX WITH A HYDROXAMATE INHIBITOR
Descriptor:Lethal factor, ZINC ION, (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE
Authors:Shoop, W.L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J.V., Felcetto, T., Michael, B.F., Bansal, A.
Deposit date:2005-02-02
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Anthrax lethal factor inhibition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZXV
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X-RAY CRYSTAL STRUCTURE OF THE ANTHRAX LETHAL FACTOR BOUND TO A SMALL MOLECULE INHIBITOR, BI-MFM3, 3-{5-[5-(4-CHLORO-PHENYL)-FURAN-2-YLMETHYLENE]-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL}-PROPIONIC ACID.
Descriptor:lethal factor, ZINC ION, (E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID
Authors:Wong, T.Y., Liddington, R.C.
Deposit date:2005-06-08
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Efficient synthetic inhibitors of anthrax lethal factor.
Proc.Natl.Acad.Sci.Usa, 102, 2005
4DV8
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ANTHRAX LETHAL FACTOR METALLOPROTEINASE IN COMPLEX WITH THE HYDROXAMIC ACID BASED SMALL MOLECULE PT8421
Descriptor:Lethal factor, ZINC ION, (2S)-6-[(4-fluorobenzyl)amino]-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide, ...
Authors:Margosiak, S.A., Sankaran, B.
Deposit date:2012-02-22
Release date:2012-03-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.632 Å)
Cite:Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorg.Med.Chem.Lett., 22, 2012
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