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6X8O
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BimBH3 peptide tetramer
Descriptor: Bcl-2-like protein 11, THIOCYANATE ION
Authors:Robin, A.Y, Westphal, D, Uson, I, Czabotar, P.E.
Deposit date:2020-06-01
Release date:2020-09-09
Last modified:2021-02-17
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association.
Structure, 29, 2021
2WH6
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Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain
Descriptor: BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ...
Authors:Kvansakul, M, Huang, D.C.S, Colman, P.M.
Deposit date:2009-05-01
Release date:2010-05-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
4QVF
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BU of 4qvf by Molmil
Crystal structure of Bcl-xL in complex with BIM BH3 domain
Descriptor: Bcl-2-like protein 1, Peptide from Bcl-2-like protein 11
Authors:Sreekanth, R, Yoon, H.S.
Deposit date:2014-07-15
Release date:2015-06-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.531 Å)
Cite:Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.
Proteins, 83, 2015
4A1U
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BU of 4a1u by Molmil
Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
Descriptor: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ...
Authors:Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
Deposit date:2011-09-20
Release date:2011-12-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
2NL9
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BU of 2nl9 by Molmil
Crystal structure of the Mcl-1:Bim BH3 complex
Descriptor: Bcl-2-like protein 11, CHLORIDE ION, FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, ...
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
6UA3
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BU of 6ua3 by Molmil
Human Mcl-1 in complex with a modified Bim BH3 peptide
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide
Authors:Mandal, T, Grant, R.A, Keating, A.E.
Deposit date:2019-09-10
Release date:2020-09-16
Method:X-RAY DIFFRACTION (1.552 Å)
Cite:Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
To Be Published
5VWY
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BU of 5vwy by Molmil
Bak core latch dimer in complex with Bim-h3Pc-RT
Descriptor: Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, PHOSPHATE ION
Authors:Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.555 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX0
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BU of 5vx0 by Molmil
Bak in complex with Bim-h3Glg
Descriptor: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
Authors:Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWZ
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BU of 5vwz by Molmil
Bak in complex with Bim-h3Pc
Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, AMMONIUM ION, Bcl-2 homologous antagonist/killer, ...
Authors:Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.622 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
1PQ1
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BU of 1pq1 by Molmil
Crystal structure of Bcl-xl/Bim
Descriptor: Apoptosis regulator Bcl-X, BCL2-like protein 11
Authors:Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W.
Deposit date:2003-06-17
Release date:2003-09-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function
Immunity, 19, 2003
5VMO
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BU of 5vmo by Molmil
Crystal structure of grouper iridovirus GIV66:Bim complex
Descriptor: 1,2-ETHANEDIOL, Bak protein, Bcl-2 interacting mediator of cell death, ...
Authors:Banjara, S, Kvansakul, M.
Deposit date:2017-04-28
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.
J. Biol. Chem., 293, 2018
3KJ0
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BU of 3kj0 by Molmil
Mcl-1 in complex with Bim BH3 mutant I2dY
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Fire, E, Grant, R.A, Keating, A.E.
Deposit date:2009-11-02
Release date:2010-02-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
3FDL
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BU of 3fdl by Molmil
Bim BH3 peptide in complex with Bcl-xL
Descriptor: Apoptosis regulator Bcl-X, Bcl-2-like protein 11
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
4ZIE
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BU of 4zie by Molmil
Crystal Structure of core/latch dimer of Bax in complex with BimBH3
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2-like protein 11
Authors:Krishna Kumar, K, Robin, A.Y, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M, Czabotar, P.E.
Deposit date:2015-04-28
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.797 Å)
Cite:Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.
Cell Death Dis, 6, 2015
2YQ6
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BU of 2yq6 by Molmil
Structure of Bcl-xL bound to BimSAHB
Descriptor: BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL
Authors:Smith, B.J, Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
5VX2
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BU of 5vx2 by Molmil
Mcl-1 in complex with Bim-h3Pc-RT
Descriptor: 1,2-ETHANEDIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1 chimera
Authors:Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWV
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BU of 5vwv by Molmil
Bak core latch dimer in complex with Bim-BH3 - Cubic
Descriptor: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
Authors:Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
4B4S
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BU of 4b4s by Molmil
Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex
Descriptor: BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL
Authors:Rautureau, G.J.P, Hinds, M.G, Kvansakul, M.
Deposit date:2012-08-01
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
Cell Death Dis., 3, 2012
2YQ7
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BU of 2yq7 by Molmil
Structure of Bcl-xL bound to BimLOCK
Descriptor: BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL
Authors:Smith, B.J, Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
5VX3
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BU of 5vx3 by Molmil
Bcl-xL in complex with Bim-h3Pc-RT
Descriptor: 1,2-ETHANEDIOL, Bcl-2-like protein 1, Bcl-2-like protein 11
Authors:Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.945 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
3KJ1
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BU of 3kj1 by Molmil
Mcl-1 in complex with Bim BH3 mutant I2dA
Descriptor: ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ...
Authors:Fire, E, Grant, R.A, Keating, A.E.
Deposit date:2009-11-02
Release date:2010-02-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.945 Å)
Cite:Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
6VBX
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BU of 6vbx by Molmil
Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide
Authors:Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z.
Deposit date:2019-12-19
Release date:2020-12-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.
J.Med.Chem., 64, 2021
3D7V
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BU of 3d7v by Molmil
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D.
Deposit date:2008-05-22
Release date:2008-06-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
4YJ4
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BU of 4yj4 by Molmil
Crystal structure of Bcl-xL in complex with the BIM BH3 domain containing Ile155-to-Arg and Glu158-to-phosphoserine mutations
Descriptor: ACETATE ION, Bcl-2-like protein 1, BIM BH3 domain, ...
Authors:Ku, B, Ha, N.-C, Oh, B.-H.
Deposit date:2015-03-03
Release date:2015-07-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain.
Cell Death Dis, 6, 2015
6UAB
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BU of 6uab by Molmil
Human Mcl-1 in complex with a modified unnatural Bim BH3 peptide
Descriptor: ADAMANTANE, Induced myeloid leukemia cell differentiation protein Mcl-1, modified unnatural Bim BH3 peptide
Authors:Mandal, T, Grant, R.A, Keating, A.E.
Deposit date:2019-09-10
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
To Be Published

 

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