2LQ7
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E2 BINDING SURFACE ON UBA3 BETA-GRASP DOMAIN UNDERGOES A CONFORMATIONAL TRANSITION
Descriptor:NEDD8-activating enzyme E1 catalytic subunit
Authors:Elgin, E.S., Peterson, F.C., Volkman, B.F.
Deposit date:2012-02-27
Release date:2012-07-25
Last modified:2013-08-28
Method:SOLUTION NMR
Cite:E2-binding surface on Uba3 beta-grasp domain undergoes a conformational transition.
Proteins, 80, 2012
3FN1
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E2-RING EXPANSION OF THE NEDD8 CASCADE CONFERS SPECIFICITY TO CULLIN MODIFICATION.
Descriptor:NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F
Authors:Huang, D.T., Ayrault, O., Hunt, H.W., Taherbhoy, A.M., Duda, D.M., Scott, D.C., Borg, L.A., Neale, G., Murray, P.J., Roussel, M.F., Schulman, B.A.
Deposit date:2008-12-22
Release date:2009-03-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
1R4M
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APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX
Descriptor:amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ...
Authors:Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
1R4N
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APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX WITH ATP
Descriptor:amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ...
Authors:Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
1TT5
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STRUCTURE OF APPBP1-UBA3-UBC12N26: A UNIQUE E1-E2 INTERACTION REQUIRED FOR OPTIMAL CONJUGATION OF THE UBIQUITIN-LIKE PROTEIN NEDD8
Descriptor:amyloid protein-binding protein 1, ubiquitin-activating enzyme E1C isoform 1, Ubiquitin-conjugating enzyme E2 M, ...
Authors:Huang, D.T., Miller, D.W., Mathew, R., Cassell, R., Holton, J.M., Roussel, M.F., Schulman, B.A.
Deposit date:2004-06-21
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11, 2004
1Y8X
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STRUCTURAL BASIS FOR RECRUITMENT OF UBC12 BY AN E2-BINDING DOMAIN IN NEDD8'S E1
Descriptor:Ubiquitin-conjugating enzyme E2 M, Ubiquitin-activating enzyme E1C
Authors:Huang, D.T., Paydar, A., Zhuang, M., Waddell, M.B., Holton, J.M., Schulman, B.A.
Deposit date:2004-12-13
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
1YOV
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INSIGHTS INTO THE UBIQUITIN TRANSFER CASCADE FROM THE REFINED STRUCTURE OF THE ACTIVATING ENZYME FOR NEDD8
Descriptor:Amyloid protein-binding protein 1, Ubiquitin-activating enzyme E1C, ZINC ION
Authors:Walden, H., Podgorski, M.S., Schulman, B.A.
Deposit date:2005-01-28
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8
Nature, 422, 2003
2NVU
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STRUCTURE OF APPBP1-UBA3~NEDD8-NEDD8-MGATP-UBC12(C111A), A TRAPPED UBIQUITIN-LIKE PROTEIN ACTIVATION COMPLEX
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, NEDD8-conjugating enzyme Ubc12, ...
Authors:Huang, D.T., Hunt, H.W., Zhuang, M., Ohi, M.D., Holton, J.M., Schulman, B.A.
Deposit date:2006-11-13
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445, 2007
3DBH
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STRUCTURAL DISSECTION OF A GATING MECHANISM PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8'S E1 (APPBP1-UBA3ARG190ALA-NEDD8ALA72ARG)
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ...
Authors:Souphron, J., Schulman, B.A.
Deposit date:2008-05-31
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008
3DBL
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STRUCTURAL DISSECTION OF A GATING MECHANISM PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8'S E1 (APPBP1-UBA3ARG190WT-NEDD8ALA72GLN)
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ...
Authors:Souphron, J., Schulman, B.A.
Deposit date:2008-06-01
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008
3DBR
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STRUCTURAL DISSECTION OF A GATING MECHANISM PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8'S E1 (APPBP1-UBA3ARG190GLN-NEDD8ALA72ARG)
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ...
Authors:Souphron, J., Schulman, B.A.
Deposit date:2008-06-02
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008
3GZN
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STRUCTURE OF NEDD8-ACTIVATING ENZYME IN COMPLEX WITH NEDD8 AND MLN4924
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ...
Authors:Sintchak, M.D.
Deposit date:2009-04-07
Release date:2010-02-02
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Mol.Cell, 37, 2010
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